Types of SteroidsAthletes and bodybuilders have recognized for several decades that the use of anabklic steroids can promote muscle growth and strength but steroiss is only relatively recently that these agents are being revisited for clinical purposes. Anabolic steroids are being considered for the treatment of cachexia associated with chronic disease states, and different classes of anabolic steroids address loss deblina chatterjee muscle mass in the elderly, but nevertheless their efficacy still needs to be demonstrated in terms of improved physical function and quality of life. In sport, these agents are performance enhancers, this being particularly apparent in women, although there is a high dfiferent of virilization despite the favourable myotrophic—androgenic dissociation that many xenobiotic steroids confer. Modulation of androgen different classes of anabolic steroids expression appears to be key to partial dissociation, with consideration of both intracellular steroid metabolism and the topology of the bound androgen receptor interacting with co-activators. An anticatabolic effect, by interfering with glucocorticoid receptor expression, remains an attractive hypothesis.
Steroids are organic compounds that hold a chemical structure characterized by a particular arrangement of four cycloalkane rings that are connected to one another. These rings are composed of at least twenty carbon atoms that are bound together, which form the ring shapes.
These rings are labeled as A, B, C and D rings. The A, B, and C rings are cycloalkane rings known specifically as cyclohexane rings rings that contain 6 carbon atoms. The D ring differs from the other rings due to the fact that it is known as a cyclopentane ring a ring that contains 5 carbon atoms.
Different steroid compounds differ based on varying structural differences centered on the primary four ring steroid structure, which may involve variations in the functional groups attached to the central four rings, or other smaller modifications such as the change in a single hydrogen, carbon, or oxygen atom. There are many different types of steroids, the majority of which do not have anything what so ever to do with muscle growth, strength, or athletic performance.
Many steroids, in fact, destroy and break down muscle tissue these are known as corticosteroids. There exist hundreds of different types of steroids and steroidal compounds in nature, and they exist in plants, animals, insects, and even fungi.
Naturally occurring steroids are synthesized in cells of the different aforementioned organisms. There exist many different types of steroids in the human body, such as: Vitamin D in particular is what is known as a secosteroid, which is a steroidal molecule but contains a broken ring.
In the human body, Cholesterol is the precursor to the development of all other steroids manufactured in the human body. The types of steroids that we are concerned with in particular are known as anabolic steroids.
These are also properly referred to also as anabolic androgenic steroids often abbreviated as AAS. This is to mean that anabolic steroids are steroids that promote tissue building or tissue growth, and in this case it refers specifically to muscle tissue anabolism.
Androgenic steroids refer to steroids that generate masculine features. The number one primary anabolic steroid manufactured in every human body and in most animal species is the hormone Testosterone. It is the male sex hormone that provides the male gender with the commonly known male traits deepening of the voice, development of bodily and facial hair, and increases in muscle size and strength.
Testosterone is responsible for governing the maintenance and control of many different functions in the human body, and muscle growth is but only one of many of these functions it is responsible for governing. There exist two other naturally endogenously produced anabolic steroids in humans: Dihydrotestosterone DHT and Nandrolone.
These are the three naturally manufactured anabolic steroids by which all other anabolic steroids are derived from and based upon. There exist hundreds of different anabolic steroids that have been synthesized and created, all of which are based on and derived from one of the three aforementioned anabolic steroid hormones Testosterone, Dihydrotestosterone, and Nandrolone.
This is to say that all anabolic steroids in existence are modified forms of Testosterone, Dihydrotestosterone, or Nandrolone. These modified variants of these hormones are what are known as anabolic steroid analogues or derivatives. That is to say that if an anabolic steroid is an analogue or derivative of Testosterone, it is simply Testosterone with a modification to its molecular chemical structure.
The following is an example of the difference between the structure of Testosterone and the structure of a known analogue of Testosterone, Methandrostenolone Dianabol:. Dihydrotestosterone analogues or Dihydrotestosterone derivatives. These are the three types of steroids. Technically, Testosterone is quite literally the original and primary anabolic steroid by which every single anabolic steroid is derived from. Within the human body, Testosterone is the precursor hormone to Dihydrotestosterone and Nandrolone.
Testosterone is metabolized into Dihydrotestosterone in the body by way of the 5-alpha reductase 5AR enzyme meaning Dihydrotestosterone is a metabolite of Testosterone , and furthermore, Nandrolone is a byproduct of the aromatization conversion of Testosterone into Estrogen [i].
Without Testosterone , Nandrolone and DHT would not even exist, which further explains that without the existence of DHT and Nandrolone, none of their analogues and derivatives would exist. Furthermore, the development of an anabolic steroid derivative will often frequently take on the same properties and characteristics of its parent hormone or progenitor hormone.
For example, a characteristic of Dihydrotestosterone DHT is its inability to convert into Estrogen because it is unable to interact with the aromatase enzyme. One additional important point to understand under the concept of analogues and their progenitor hormones is the following: However, that is in theory. In practice what may occur is the opposite, or a differing effect.
But we still properly refer to them, for example, as DHT or DHT derivatives or Testosterone derivatives , Nandrolone derivatives , and so on and so forth. Testosterone is the number one naturally endogenously manufactured anabolic steroid by the human body, and it is the root anabolic steroid for the synthesis of all other anabolic steroids in existence.
The concept behind chemically altering and modifying Testosterone is to create variants and analogues of Testosterone that could exhibit varying effects in the body that may be more beneficial in certain areas of function than Testosterone originally would be. Such modifications would allow a particular anabolic steroid analogue to be more preferable to treat a certain condition or disease in medicine than Testosterone itself would be able to. One particularly specific goal behind the creation of different types of steroids is the quest to create what would be considered a perfect anabolic steroid.
This is evidenced by the anabolic steroid development boom of the s — s. When the concept of anabolic steroids for the purpose of performance and physique enhancement is considered, the idea behind the use of different anabolic steroid types is quite clear.
The first obvious idea behind the development and use of different analogues is that of the use or discovery of an anabolic steroid analogue that would exhibit a stronger anabolic effect than Testosterone itself. If a stronger anabolic effect with a reduced strength in androgenic effects is created, an anabolic steroid that exhibits less undesirable side effects and more of the desirable anabolic effects would be favorable to an athlete.
This is also the concept behind the use of an anabolic steroid that would provide the athlete with less negative effects while exhibiting more of the positive effects. In creating different types of steroids and analogues, different anabolic steroids can exhibit different attributes that are favorable to the athlete in comparison to Testosterone itself, which may present some disadvantages for athletes in various areas. This is especially true for athletes involved in various sporting activities in which the use of Testosterone or various other anabolic steroids are unfavorable due to various attributes they may have that could possibly reduce performance in specific athletic activities.
For example, anabolic steroids such as Testosterone have a tendency to promote water retention through their ability to be aromatized into Estrogen via the aromatase enzyme. While such an effect might not be a concern for a strength athlete or a powerlifter such an effect might even be beneficial or desired in such sports , this is not a desired effect for athletes involved in sports that involve speed and swiftness, such as sprinting.
Instead, a sprinter, for example, would more likely opt for an anabolic steroid such as Stanozolol Winstrol or Oxandrolone Anavar , which are two anabolic steroids unable to convert into Estrogen and therefore the issue of water retention, and therefore the issue of added weight that would slow the athlete down is avoided. In the case of cycle stacks, an individual might be able to increase the synergy and synergistic effects between the anabolic steroids to create a highly anabolic environment or to create a stack that might assist the user in favoring certain particular athletic or physique goals.
These are some of the major reasons as to why the development of different types of steroids has been done. It is actually quite ironic in the sense that the very first officially created derivative of Testosterone Dianabol was actually designed for the purpose of athletic performance in mind — not for the purpose of medical use. A very small but extremely important note must be made for the reader to remember prior to discussing the various types of steroids and derivatives.
It is extremely important to understand that Testosterone is utilized as the measuring stick or the measuring bar whereby all other anabolic steroids are measured against, referenced with, and compared to much like the celsius scale of temperature measurement where the freezing point and boiling points of water are used as the baseline measurements for temperature.
The importance of the anabolic and androgenic strength ratings of respectively is paramount to understanding the different strengths of the various types of steroids.
Derivatives of Testosterone will of course possess and exhibit some or many of the same properties of Testosterone, and this can present both advantages and disadvantages which will be explained and covered in detail here. The very first officially created Testosterone analogue is Methandrostenolone Dbol , followed by Boldenone Equipoise.
These two analogues will be utilized here as examples. The general characteristics of Testosterone derivatives are very similar to that of Testosterone: However, the reduction of these analogues into their respective stronger androgenic metabolites differs from Testosterone in that they are reduced into very small trace amounts usually the result of the structural modifications allowing these anabolic steroid analogues to possess a lesser affinity to bind to the 5AR enzyme.
In terms of the actual structural modifications, we will first examine Dianabol Methandrostenolone. Dianabol is basically Testosterone that has been methylated at carbon alpha on its structure this is simply the addition of a methyl group at the 17 th carbon. This process, known as CAlpha Alkylation, allows the anabolic steroid to be administered orally and still have a measurably strong effect on the body. Without this modification, it is impossible for any anabolic steroid to survive liver metabolism in significant enough quantities to promote any measurable effects in the body — the result is that extremely miniscule amounts of the anabolic steroid reaches the bloodstream to perform its job.
Dianabol also possesses a double-bond between carbons 1 and 2. All of these modifications are what grant Dianabol with its increases in anabolic strength and reduced androgenic strength in comparison to Testosterone. Equipoise Boldenone is very easy to describe after understanding Dianabol. Equipoise is simply Dianabol without the methyl group attached to carbon alpha.
Dianabol itself possesses moderate Estrogenic activity in the body, while Equipoise possesses low Estrogenic activity in the body. It is very evident that the structural modifications to Testosterone that result in both Dianabol and Equipoise grant one of them lower Estrogenic activity than Testosterone itself, but does not eliminate it. Testosterone analogues, because of their ability to still exhibit Estrogenic activity at some level, will commonly be preferred by users as anabolic steroids that are utilized in bulking or mass-gaining cycles due to the fact that the water retention associated with it is typically undesirable during periods of cutting or fat loss.
This is because the water retention can cause the physique to take on a bloated and soft look. Therefore, the use of compounds such as Dianabol is generally limited as such.
But this is not to say that Dianabol cannot be utilized for fat loss or cutting. Any anabolic steroid can be utilized for any purpose. There exist no such possible things except for anabolic steroids that may be preferred for cutting, bulking, or lean mass depending on their attributes and properties that are associated with side effects that may be undesirable for the goal of cutting or bulking.
Quite simply put, Dihydrotestosterone analogues are different types of steroids that are derived from Dihydrotestosterone. These are anabolic steroids that essentially utilize Dihydrotestosterone as the base template for the modifications to the core Dihydrotestosterone chemical structure.
The fact is that the majority of anabolic steroids are Dihydrotestosterone derivatives, because research and history has shown that Dihydrotestosterone analogues exhibit very promising results in the different changes and modifications that result in the different Dihydrotestosterone variants.
Dihydrotestosterone derivatives belong to the family of DHT-derivatives such as Winstrol, Anavar , Primobolan, Masteron and several others.
However, Dihydrotestosterone is a very unique anabolic steroid in the sense that it holds absolutely no activity within muscle tissue, which is a very interesting detail in and of its self. All anabolic steroids that belong to DHT-derivative family contain modifications to their chemical structures that grant them significant activity and effectiveness within muscle tissue, where DHT itself unmodified would never survive metabolism there.
This is because Dihydrotestosterone, once it enters muscle tissue, is instantly deactivated and metabolized into two ineffective hormones by an enzyme. This enzyme is the 3-hydroxysteroid dehydrogenase enzyme, which is present in large quantities in muscle tissue, and is the enzyme that serves to metabolize any DHT that enters muscle tissue into two inactive metabolites: These two hormones which are metabolites of DHT are not anabolic what so ever in muscle tissue.
This is therefore the reason as to why DHT is not anabolic in muscle tissue at all, and many chemists and biologists believe that if this enzyme 3-hydroxysteroid dehydrogenase did not exist in muscle tissue, that DHT would actually be a very potent and powerful anabolic steroid.
Therefore, it would be an error to simply refer to DHT as only an androgenic steroid. It indeed holds the capability to be anabolic, but it is unfortunately stripped of that experience as soon as it enters muscle tissue by the enzyme 3-hydroxysteroid dehydrogenase.
The evidence that DHT is in fact a very anabolic hormone lies in the fact that its derivatives become anabolic due to the fact that their chemical modifications eliminate the affinity for the hormone to interact with the 3-hydroxysteroid dehydrogenase enzyme. Masteron Drostanolone will be used as a simple example and explanation here. Masteron is essentially DHT with a methyl group at the 2 nd carbon known as carbon alpha atom has been added.
This modification is what is known to be responsible for the slight anabolic strength increase in comparison to Testosterone. This methyl group addition increases the anabolic strength by way of granting Masteron an increased resistance to being metabolized into inactive metabolites by the enzyme 3-hydroxysteroid dehydrogenase. The only exception to this case is Anadrol Oxymetholone , where it possesses a high degree of Estrogenic activity, but this is not due to interaction with the aromatase enzyme — it cannot interact with the aromatase enzyme.