Human Growth Hormone (HGH)Growth hormone is a protein hormone of about amino acids that is synthesized and secreted by groath called somatotrophs in the anterior pituitary. It is a major participant in control of several complex physiologic processes, including growth and metabolism. Growth hormone is also of considerable interest as a drug used in both humans and animals. A critical concept human growth hormone protein understanding growth hormone activity is that it has two distinct types of effects:. Keeping this distinction in mind, we can discuss two major roles of pgotein hormone and its minion IGF-I in human growth hormone protein. Growth is a very complex process, and requires the coordinated action of several hormones.
Human Growth Hormone (HGH)
Systems used to automatically annotate proteins with high accuracy:. Select item s and click on "Add to basket" to create your own collection here entries max. Comprehensive resource for the study of protein post-translational modifications PTMs in human, mouse and rat. The displayed sequence is further processed into a mature form. Additionally, this section gives relevant information on each alternative protein isoform. Align Add to basket Added to basket.
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. The sequence of this isoform differs from the canonical sequence as follows: You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Your basket is currently empty. Reviewed - Annotation score: Select a section on the left to see content. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. Circulating GH shows a great heterogeneity due to alternative splicing, differential post-translational modifications of monomeric forms, oligomerization, optional binding to 2 different GH-binding proteins, and potentially proteolytic processing.
Growth hormone Short name: Endosome endosome lumen Source: Reactome Extracellular region or secreted extracellular region Source: Reactome extracellular space Source: Disease description An autosomal recessive, severe deficiency of growth hormone leading to dwarfism. Patients often develop antibodies to administered growth hormone.
III , Scanlon M. Disease description An autosomal recessive deficiency of growth hormone leading to short stature. Patients have low but detectable levels of growth hormone, significantly retarded bone age, and a positive response and immunologic tolerance to growth hormone therapy.
Disease description A syndrome clinically characterized by short stature associated with bioinactive growth hormone, normal or slightly increased growth hormone secretion, pathologically low insulin-like growth factor 1 levels, and normal catch-up growth on growth hormone replacement therapy. Disease description An autosomal dominant deficiency of growth hormone leading to short stature.
Clinical severity is variable. Patients have a positive response and immunologic tolerance to growth hormone therapy. Used for the treatment of growth hormone deficiency and for Turner's syndrome. The primary structure of the hormone. The primary structure of the hormone: CleanEx database of gene expression profiles More Genevisible search portal to normalized and curated expression data from Genevestigator More Organism-specific databases Human Protein Atlas More Can also form a complex either with GHBP or with the alpha2-macroglobulin complex.
Align Add to basket Added to basket Note: Additional isoforms seem to exist. It is useful for tracking sequence updates. The algorithm is described in the ISO standard. No experimental confirmation available. Growth hormone 1 isoform 2 2 Full view. Isoform 5 of Somatotropin 22 Full view. Isoform 5 of Somatotropin Full view. EMBL nucleotide sequence database More These are stable identifiers and should be used to cite UniProtKB entries.
P Secondary accession number s: Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest. Reactome - a knowledgebase of biological pathways and processes More Synthesis, secretion, and deacylation of Ghrelin. Growth hormone receptor signaling. Somatotropin Alternative name s: GH-N Growth hormone 1 Pituitary growth hormone.
Four distinct tokens exist: It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first. They may also represent different stages in a genome project and include components such as contigs, scaffolds or Whole Genome Shotgun WGS master records. Eukaryotic Pathogen Database Resources More Human Gene Nomenclature Database More Corresponds to variant dbSNP: MalaCards human disease database More Orphanet; a database dedicated to information on rare diseases and orphan drugs More Isolated growth hormone deficiency type IA.
Isolated growth hormone deficiency type IB. Isolated growth hormone deficiency type II. Short stature due to growth hormone qualitative anomaly. BioMuta curated single-nucleotide variation and disease association database More PaxDb, a database of protein abundance averages across all three domains of life More Human Protein Atlas More Database of interacting proteins More Protein interaction database and analysis system More Select the link destinations: Protein Data Bank Europe More PDBj i Links Updated.
Database of comparative protein structure models More Relative evolutionary importance of amino acids within a protein sequence More Non-supervised Orthologous Groups More Eukaryotic Ortholog Groups More Database of Orthologous Groups More Database for complete collections of gene phylogenies More TreeFam database of animal gene trees More Integrated resource of protein families, domains and functional sites More Pfam protein domain database More View protein in Pfam PF Protein Motif fingerprint database; a protein domain database More Superfamily database of structural and functional annotation More These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples.
Sequence conflicts are usually of unknown origin. The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence s for display.
Missing in isoform 5. Missing in isoform 2. Missing in isoform 3. Missing in isoform 4. Protein sequence database of the Protein Information Resource More UniGene gene-oriented nucleotide sequence clusters More Ensembl eukaryotic genome annotation project More