Seretide 100 AccuhalerThis multicentre double-blind, double-dummy study compared the safety and efficacy of a new combination Diskus inhaler containing both salmeterol 50 microg and fluticasone propionate microg Seretide, GlaxoWellcome, France with the same doses of the two drugs delivered via separate Diskus inhalers and with the same dose of fluticasone propionate alone. Patients were eligible for study entry if they had received an inhaled corticosteroid seretide propionate de fluticasone for 12 weeks prior to run-in, and seretide propionate de fluticasone received treatment with beclomethasone dipropionate or budesonide microg day -1 or how to build mass without steroids propionate microg day -1 for at least 4 weeks prior to run-in. All treatments were administered twice daily, mean morning peak propioante flow rate PEFR and asthma symptoms were measured for the first 12 weeks and safety data were collected throughout the seretide propionate de fluticasone study. All three treatments were well tolerated. In addition, there were no differences between the three treatments in either the c.
Seretide (Fluticasone propionate/Salmeterol xinafoate) Drug / Medicine Information
Seretide evohaler and Seretide accuhaler are combined corticosteroid and bronchodilator inhalers used to reduce inflammation in the lungs and open the airways in asthma and COPD.
They are purple in colour. Seretide is prescribed for people whose asthma isn't controlled by using a regular preventer inhaler a corticosteroid with a reliever inhaler eg salbutamol used when needed to open the airways.
Seretide doesn't cure asthma - it's used to help manage and control your asthma. Seretide should be used regularly, even when you have no asthma symptoms, to reduce the inflammation in the lungs and to help keep the airways open. You should still keep your reliever inhaler with you at all times in case you do have an asthma attack. Seretide is used for people with severe COPD who have repeated attacks of breathlessness, despite using long-acting bronchodilators such as formoterol or salmeterol on a regular basis.
Seretide accuhaler and evohaler both contain two active ingredients, a corticosteroid called fluticasone propionate and a bronchodilator called salmeterol xinafoate.
Corticosteroids are hormones that are produced naturally by the adrenal glands. They have many important functions, including control of inflammatory responses. Fluticasone is a man-made derivative of the natural hormones and is used to decrease inflammation in the lungs. Corticosteroids are often simply called steroids, but note they are not the same as anabolic steroids, which are abused by some athletes and body builders.
When you breathe in fluticasone it's absorbed into the cells of the lungs and airways. It stops these cells from releasing chemicals that normally cause immune and allergic responses resulting in inflammation. By stopping these chemicals being released, fluticasone reduces inflammation in lungs that tightens the airways and makes it difficult for air to get in and out.
Used regularly, fluticasone helps prevent asthma attacks and shortness of breath. Salmeterol is a type of medicine called a long-acting beta 2 agonist. It works by relaxing the muscles in the airways and allowing the airways to open, making it easier to breathe. Salmeterol doesn't open the airways as quickly as short-acting beta 2 agonists such as salbutamol or terbutaline, however, it does keep the airways open for much longer.
The effects of salmeterol last for about 12 hours, whereas those of salbutamol or terbutaline last for about 3 to 5 hours. This means salmeterol is used to prevent asthma attacks, wheezing, chest tightness and shortness of breath, rather than to relieve them. You must use your Seretide inhaler regularly every day, usually twice a day but sometimes reducing to once a day if your asthma is well controlled.
You should always follow the instructions given by your doctor regarding when to use your inhaler and how many inhalations you should use each day. Don't exceed the prescribed dose. Don't suddenly stop using Seretide, even if you don't currently have any breathing problems, unless your doctor tells you otherwise.
Stopping treatment is likely to make your breathing problems flare-up again. It's very important to learn how to use your inhaler correctly, as otherwise you won't be breathing the right dose of medicine into your lungs.
Instructions will be provided with your inhaler. However, your doctor, nurse or pharmacist can also show you how to use your inhaler and can check that you are using it correctly. Seretide is available as two different types of inhaler device; the evohaler and the accuhaler. Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that may be associated with fluticasone and salmeterol.
Just because a side effect is stated here, it does not mean that all people using Seretide inhalers will experience that or any side effect. Inhaled corticosteroids have considerably fewer side effects than steroids taken by mouth. However, when taken for long periods of time at high doses, they do have the potential to cause rare side effects such as glaucoma , thinning of the bones osteoporosis , Cushing's syndrome , slowed growth in children and adolescents, changes in mood or behaviour, including hyperactivity and irritability in children, and to suppress the functioning of the adrenal glands glands that produce natural steroid hormones.
Your doctor will always prescribe the lowest effective dose to control your symptoms, and monitor for these side effects. Tell your doctor if you experience blurred vision or any other changes in your vision while using Seretide. Children having long-term treatment with corticosteroids should have their height and weight monitored. If a child's growth appears to be slowed your doctor may refer them to a paediatrician. For more information talk to your doctor or pharmacist.
If you want more information about possible Seretide side effects you should read the leaflet that comes with your inhaler or talk to your doctor or pharmacist.
If you think you or your child have experienced a side effect, did you know you can report this using the yellow card website? It's important to tell your doctor what medicines you're already using, including herbal medicines and those bought without a prescription, before you start using Seretide. You should also check with your doctor or pharmacist before taking any new medicines while you're using Seretide, to make sure that the combination is safe.
This is particularly important if you've been using or want to use other medicines that contain corticosteroids , for example steroid nasal sprays for hayfever, or steroid creams for eczema. You may be more likely to get side effects if you're using more than one type of steroid medication and your doctor may want to monitor you more closely. Remember that some medicines might not be suitable for you because you have asthma or COPD, rather than because you are using Seretide to treat it.
People who are using Seretide should not usually take medicines called beta-blockers, such as atenolol, propranolol or timolol. This is because beta-blockers have an opposite action to salmeterol and can cause the airways to narrow.
This can result in breathing difficulties for people with asthma or COPD. This problem has also sometimes been seen with eye drops containing beta-blockers, eg used for glaucoma. Seretide may potentially decrease the amount of potassium in your blood. If you're using it with any of the following medicines, which can also lower blood potassium levels, your blood potassium is more likely to fall too low.
A low blood potassium level can have serious effects, so people with severe asthma, who may be taking several of these medicines, should have their blood potassium level monitored regularly:.
People taking digoxin may have an increased risk of abnormal heart rhythms if they experience abnormally low blood potassium levels while using Seretide. The following medicines may increase the amount of salmeterol or fluticasone that is found in the bloodstream after inhaling a dose of Seretide:. These medicines can therefore increase your exposure to fluticasone and salmeterol and so may increase the risk of side effects on the rest of the body. Due to the risk of systemic steroid side effects, such as decreased production of natural steroid hormones by the adrenal glands adrenal suppression and Cushing's syndrome, Seretide is not recommended for people who are taking ritonavir.
The antifungals ketoconazole and itraconazole should be used with caution in people using Seretide. Long courses of treatment with these antifungals should be avoided where possible. The following inhalers contain both salmeterol and fluticasone as the active ingredients:.
Flixotide contains just fluticasone. Serevent contains just salmeterol. Like Us On Facebook. Follow Us On Pinterest Netdoctor. Cancer Depression Diabetes Digestive health All conditions.
Health tips Fitness Sexual health Mental health Healthy travel. What your semen says about your health. Paula Radcliffe on the health condition you probably didn't realise she had. What happens to your body when you grieve? This has been the bestselling skincare product on Amazon for the past decade. Fertility Pregnancy Baby and toddler Teens.
Top tips for tackling fussy eating at Christmas. What nutritionists feed their children. How to navigate the festive season if you're having fertility treatment. Do these 6 winter health foods and supplements actually work? Himalayan pink sea salt isn't as healthy as you think it is. An expert guide to plant-based milks. What are Seretide inhalers used for? Asthma — what to tell your doctor during a consultation. Seretide evohaler is a metered dose inhaler sometimes called an MDI or aerosol inhaler that delivers the medicine as a fine spray or mist.
With this inhaler you have to co-ordinate pressing down the canister and breathing in the spray. Asthma — the importance of keeping a daily asthma diary. What are the possible side effects of Seretide? Very common affect more than 1 in 10 people Headache.
Increased number of colds in people with COPD. Common affect between 1 in 10 and 1 in people Thrush infection of the mouth and throat oral thrush. This can usually be avoided by rinsing the mouth out with water and spitting it out immediately after each time you use your inhaler.
If you do get oral thrush your doctor can prescribe an antifungal medicine to treat it. Pain in the muscles or joints. Sinusitis in people with COPD. Low level of potassium in the blood in people with COPD. Pneumonia and bronchitis in people with COPD. Bruising or bone fractures in people with COPD. Uncommon affect between 1 in and 1 in people Feeling shaky tremor.
Awareness of your heartbeat palpitations. Increased heart rate tachycardia. Increased blood sugar level hyperglycaemia. Is it dangerous to take different medicines at the same time?