Europe PharmaceuticalHuman growth hormone has produced many names, a peptide and one of the most anabolic hormones is human growth hormone europe pharmaceutical is the man to build mass. The HGH plays a very central role in the early years of our childhood during the growth spurts often occur there. The natural production and secretion of GH occurs place mainly during sleep and is influenced by human growth hormone europe pharmaceutical factors, eurpoe as our diet and exercise. After its release into the blood by the pituitary gland HGH has very many features. Human growth hormone is a protein which causes a size growth and accelerate cell division in the cells.
Global Human Growth Hormone Drugs - Pharmaceuticals
It has been shown that as we age, our bodies' natural GH production decreases. Many of the effects of aging are seen as a result of this decrease. More important, clinical evidence and recent medical research clearly demonstrate that by replacing Human Growth Hormone in IGF-1 deficient adults, we can significantly eliminate these symptoms, reverse the biological effects of aging, reduce body fat, increase lean muscle mass, strengthen the heart and improve sexual performance.
No other substance known to medical science has been shown continually to deter and reverse the process of aging. In many cases, you can reasonably look to reverse ten to twenty years of age decline with one year of continual therapy. Injectible Human Growth Hormone Available! Human Growth Hormone is an endocrine Hormone that is produced by the anterior portion of the pituitary gland. It is made up of amino acids. Production of GH decreases as we age.
Virtually every system in the human body is in some way dependent on HGH for proper functioning. Growth Hormone peaks during adolescence and decreases dramatically thereafter.
Levels are measured by IGF Growth hormone promotes the action of insulin. By getting rid of abdominal fat, you can induce greater insulin sensitivity. Greater insulin sensitivity can help prevent, and in some cases reverse type 2 adult onset diabetes. The decline of the male and female libido is directly related to the age-related declines in Hgh and Testosterone in the body. Interviews with people on Hgh Replacement Therapy indicate that almost everyone, men and women, had improvement in sexual function.
GH also has an anabolic effect on soft tissue such as tendons, cartilage, and other connective tissue. This signifies that old injuries can repair at an accelerated rate and with more strength due to stronger connective tissue.
When we age without Rejuvenation, the efficiency of our overall endocrine system i. The receptor sites also start to lag and some become switched off -- and as in menopause some disappear altogether. Thus the receptor sites target areas for some hormones messengers which are no longer there. This problem demonstrates why some improperly administered HRT therapies are not effective. The goal of restoring, retuning and maintaining youthful hormone levels helps to jumpstart tired worn receptors.
Thus it is essential that doctor administered protocols, with the help of doctors assistants for monitoring therapies are followed properly. Proper and timely Dosage Administration along with guidance in nutrition, adds a synergy with gratifying, satisfying results. GH itself is not responsible for the majority of the effects seen from GH use.
Growth hormone treatment refers to the use of growth hormone GH as a prescription medication - it is one form of Hormone therapy. Growth hormone is a peptide hormone secreted by the pituitary gland that stimulates growth and cell reproduction. In the past, growth hormone was extracted from human pituitary glands. GH is now produced by recombinant DNA technology and is prescribed for a variety of reasons. GH therapy has been a focus of social and ethical controversies for 50 years.
This article describes the history of GH treatment, current uses and risks arising from GH use. Other articles describe GH physiology , diseases of GH excess acromegaly and pituitary gigantism , deficiency , the recent phenomenon of HGH controversies , growth hormone in sports , and growth hormone for cows.
Growth hormone deficiency is treated by replacing GH. As GH is a large peptide molecule, it must be injected into subcutaneous tissue or muscle to get it into the blood. Nearly painless insulin syringes make this less trying than is usually anticipated, but perceived discomfort is a subjective value.
When treated with GH, a deficient child will begin to grow faster within months. Other benefits may be noticed, such as increased strength, progress in motor development , and reduction of body fat. Side-effects of this type of physiologic replacement are quite rare. Known risks and unsettled issues are discussed below, but GH-deficient children receiving replacement doses are at the lowest risk for problems.
Still, costs of treatment in terms of money, effort, and perhaps quality of life are substantial. Treatment of children usually involves daily injections of growth hormone, usually for as long as the child is growing. Lifelong continuation may be recommended for those most severely deficient as adults.
Most pediatric endocrinologists monitor growth and adjust dose every 3—4 months. Assessing the psychological value of treatment is difficult, but most children and families are enthusiastic once the physical benefits begin to be seen.
Little except the cost of treating severely deficient children is controversial, and most children with severe growth hormone deficiency in the developed world are offered treatment.
The story is very different for adult deficiency. GH replacement therapy can provide a number of measurable benefits to GH-deficient adults. Despite the potential benefits, most adults with GH deficiency are not being treated due to a combination of factors such as unwillingness of some adults to seek medical care, unacceptability of injections, inadequate insurance coverage, and significantly lower rates of diagnosis and treatment offered by internist endocrinologists [ citation needed ].
A peer-review article published in indicates that "Growth hormone GH replacement unequivocally benefits growth, body composition, cardiovascular risk factors and quality of life. Less is known about the effects of GH on learning and memory.
As of , GH has been approved by the U. Food and Drug Administration for treatment of other conditions:. Everything discussed in this section involves either studies to see if GH could be useful for other diseases or conditions, or off-label uses that doctors have developed in the course of their daily work.
None of the uses described below have been approved by the FDA. Post-transplant growth failure sometimes improves with GH. Many children who suffer from chronic renal, liver , and heart disease grow poorly for years before a transplant is required or available.
While growth may improve after correction of organ function by successful transplantation, the immunosuppressive drugs taken to protect the transplanted organ may continue to interfere with growth.
Growth hormone may help offset these effects and is sometimes offered in these circumstances. X-linked hypophosphatemic rickets is an inherited disorder of phosphorus metabolism that results in growth failure and rickets. GH has been shown to accelerate growth modestly.
Inflammatory bowel disease ulcerative colitis and Crohn's disease can impair growth before producing obvious bowel symptoms.
Stunted growth can be a result of Coeliac Disease damaging the intestines and preventing proper nutrient absorption. Treatment involves a gluten-free diet. HGH treatment has been used in an attempt to recover lost growth due to this effect.
Poor growth is a part of Noonan syndrome and many other genetic syndromes. Many short children with various syndromes have been treated with GH. As a broad generalization, GH for several years usually produces faster growth, and perhaps 1—2 in 2. Small numbers of children with various forms of bone dysplasia dwarfism in common parlance have been treated with GH with modest increases in short-term height velocity. No long-term studies have demonstrated increased adult height, and dwarfism due to bone dysplasia remains the prime example of extreme shortness considered not very amenable to GH treatment.
On occasion, GH has been used for other purposes than accelerating growth or replacing deficiency. Nearly every hormone available for administration has been given to non-deficient people in hope of obtaining improvement for various conditions for which other treatments are unsatisfactory.
With a few exceptions, benefits are modest and side-effect risk is higher. Experience with GH has yielded the same results. The following is not an exclusive list. Due to the immunostimulatory effect of GH,  it can enhance immunorecevory after radiation in mice and nonhuman primates. Alzheimer's disease are connected with the decline of growth hormone levels,  therefore some authors suggest that it is necessary to evaluate the use GH as future antinuerodegenerative strategy.
Other scientists have explored whether hGH treatment could be useful in adults that are not severely deficient in GH. Treatment of healthy, normally aging individuals found the only benefit to be a slight increase in muscle mass, with frequent side-effects and no evidence that it is safe to use long-term.
GH has been given to attempt to promote healing of large burns by reducing the amount of protein breakdown during the early post-injury period. GH has been used as an adjunct to caloric restriction to attempt to treat obesity. GH promotes lipolysis and reduces proteolysis. It was hoped that GH would reduce muscle breakdown without interfering with use and reduction of fat as the body shifted to a near- starvation economy. Results showed potential benefit, but this has not been widely adopted for a variety of reasons cost, injections, potential aggravation of insulin resistance , etc.
Recent studies suggest that side-effects, in particular, insulin resistance, may outweigh the potential benefits of such therapy. Fibromyalgia and chronic fatigue syndrome are poorly understood and vaguely defined conditions with overlapping features. After demonstration of disordered GH secretion and higher rates of tissue breakdown in patients with these conditions, a few people tried growth hormone treatment to see whether energy or healing could be improved.
Disturbances of GH secretion may be secondary phenomena and not causal. Despite anecdotal reports of improvement, no large, controlled trials have demonstrated significant, persistent improvement, and GH is not a common or standard treatment for either condition.
GH has been illegally taken by athletes wanting to increase recovery, strength, and power. Some scientific research has been conducted to determine whether such use could be safe and effective -- see Growth hormone in sports. The New England Journal of Medicine published two editorials in expressing concern about off-label uses of HGH and the proliferation of advertisements for "HGH-Releasing" dietary supplements, and emphasized that there is no evidence that use of HGH in healthy adults or in geriatric patients is safe and effective - and especially emphasized that risks of long-term HGH treatment are unknown.
One editorial was by Jeffrey M. Mary Lee Vance, who provided the NEJM's editorial original, cautious comment on a much cited study on the use of HGH in geriatric patients with low growth hormone levels.
A small but controlled study of GH given to severely ill adults in an intensive care unit setting for the purpose of increasing strength and reducing the muscle wasting of critical illness showed a higher mortality rate for the patients having received GH. GH treatment usually decreases insulin sensitivity ,  but some studies showed no evidence for increased diabetes incidence in GH-treated adult hypopituitary patients.
In past it was believed that GH treatment could increase the cancer risk; a large study recently concluded that "With relatively short follow-up, the overall primary cancer risk in patients receiving GH as adults was not increased. The FDA issued a Safety Alert in August , communicating the fact that a French study found that persons with certain kinds of short stature idiopathic growth hormone deficiency and idiopathic or gestational short stature treated with recombinant human growth hormone during childhood and who were followed over a long period of time, were at a small increased risk of death when compared to individuals in the general population of France.