Adult growth hormone deficiencyMar 06, Author: GH deficiency in adults usually manifests as reduced physical performance and impaired psychological human growth hormone deficiency in adults symptoms. It results in alterations in trenbolon kupie physiology of different systems of the body, manifesting as altered lipid metabolism, increased subcutaneous visceral fat, decreased muscle mass, decreased bone density, low exercise performance, and reduced quality of life. Adult GH deficiency can be a transition from childhood-onset GH deficiency or can be acquired during adulthood. The majority of cases are caused by pituitary tumors or by their treatment with surgery, radiation therapy, or both. Traumatic brain injury is another important cause. The goals of GH therapy in adults are to improve conditioning and strength, improve quality tren 75 life, and decrease the burden of associated medical conditions such as cardiovascular disease and reduced bone mineral density.
Adult-onset growth hormone deficiency | You and Your Hormones from the Society for Endocrinology
Adult-onset growth hormone deficiency is a medical condition that occurs when the body does not produce enough growth hormone. Growth hormone is made by the anterior pituitary gland. It stimulates the release of another hormone called insulin -like growth factor 1, which is produced mainly by the liver. Together, these hormones produce growth in childhood and, in adult life, have widespread metabolic effects throughout the body. Growth hormone deficiency is classified depending on when, or at what stage of life, the growth hormone deficiency first becomes evident.
There are some adults who were diagnosed as growth hormone deficient when they were children childhood-onset growth hormone deficiency and there are others who become growth hormone deficient once they reach adult life adult onset. Pituitary damage can also result from radiotherapy to the brain for other tumours close to the pituitary gland or for leukaemia , from severe head injury, autoimmune disease or from interference with the blood supply to the pituitary gland as for example in Sheehan's syndrome or pituitary apoplexy.
Most other types of growth hormone deficiency are caused by genetic abnormalities e. Prader-Willi syndrome or Turner syndrome or by abnormal development of the pituitary gland in the foetus see the article on childhood growth hormone deficiency. These are usually diagnosed at birth or in early childhood, but growth hormone deficiency is a lifelong condition and treatment may be needed in adult life see the article on childhood-onset growth hormone deficiency.
In some cases, no obvious cause for the deficiency can be found and the condition is said to be idiopathic. Adults with growth hormone deficiency may have a wide range of symptoms. When these symptoms are severe, they can reduce people's ability to function — both socially and professionally — and this can dramatically lower the quality of their lives.
It is estimated that, in the adult UK population at any given time, approximately one in every 10, people will have adult onset growth hormone deficiency. If the adults with childhood-onset and adult-onset growth hormone deficiency are combined, the estimated number is three in every 10, people.
This works out to approximately 12, adults with growth hormone deficiency in England and Wales. Adult-onset growth hormone deficiency is not normally an inherited condition. However, there are a few rare genetic abnormalities that can cause growth hormone deficiency, but these causes are rare and generally identified in childhood. The commonest test is the insulin tolerance test. This involves giving an injection of insulin to the patient to lower the blood sugar level.
During this stress reaction, the body normally releases growth hormone. Failure to produce an adequate amount of growth hormone in response to this stress is defined as growth hormone deficiency.
Most patients find the test a little uncomfortable but the unpleasant symptoms do not usually last long and, if severe, can be stopped by giving glucose without invalidating the test. The insulin tolerance test should not be carried out in patients with known heart disease or epilepsy. Alternative tests are also available in which growth hormone-releasing hormone , arginine or glucagon are used to cause growth hormone release. These tests should be carried out in a specialist unit, experienced in performing these tests safely.
The tests usually take two to four hours and can be carried out as outpatient or day case procedures. Patients may be asked not to eat before these tests. Adult-onset growth hormone deficiency is treated with growth hormone replacement treatment. The growth hormone that is used is an artificial preparation that individuals can administer themselves. This is done using daily injections underneath the skin into the fat tissue around the lower abdomen, with an injection device.
The needles are the same as those used by people who inject insulin for diabetes and the injections are virtually painless. However, there are needle-free devices available for patients who are unable to overcome the fear of injecting. Treatment starts as an outpatient with education and support, usually from an endocrine nurse. Once started, individuals are carefully monitored and given regular blood tests.
Side-effects from growth hormone therapy are infrequent and tend to occur when the dose is too high. Fluid retention and discomfort in the joints are reported, but decreasing the dosage temporarily can relieve these. Growth hormone treatment can also increase blood sugar levels. A small number of people can have increased pressure in the brain that can cause headaches and blurred vision.
Stopping treatment will resolve this problem. People with adult-onset growth hormone deficiency have an increased risk of heart disease and strokes as a result of the physical changes that occur in body fat , cholesterol and circulation. Healthy living, a balanced diet and exercise to prevent becoming overweight are essential to reduce this risk.
People with adult-onset growth hormone deficiency also have a higher risk of developing osteoporosis or brittle bones and, therefore, have a higher risk of developing fractures from minor injuries. In order to decrease these risks, having a diet that is rich in calcium and taking adequate amounts of vitamin d , along with moderate amounts of weight-bearing exercise and resistance training, are all helpful. About Contact Events News. You and Your Hormones. Students Teachers Patients Browse.
Home Endocrine conditions Adult-onset growth hormone deficiency. Adult-onset growth hormone deficiency Adult-onset growth hormone deficiency is where the pituitary gland fails to produce enough growth hormone. It can be successfully treated with growth hormone therapy. Alternative names for adult-onset growth hormone deficiency Adult growth hormone deficiency syndrome; adult GH deficiency; growth hormone deficiency; GHD What is adult-onset growth hormone deficiency?
What causes adult-onset growth hormone deficiency? What are the signs and symptoms of adult-onset growth hormone deficiency? How common is adult-onset growth hormone deficiency? Is adult-onset growth hormone deficiency inherited? How is adult-onset growth hormone deficiency diagnosed? How is adult-onset growth hormone deficiency treated? Are there any side-effects to the treatment?
Taking growth hormone will not cause any increase in height in adults. What are the longer-term implications of adult-onset growth hormone deficiency?