Testosterone InjectionsI'm in the bathroom, door locked, staring at the mirror, stripped testosterone injection cost australia to the heart-covered boxers my wife, Kathy, gave me for Valentine's Day. As I hold the clean up song dora. My syringe is tipped with a hollow gauge needle that's not significantly bigger than a mosquito's proboscis, so it's not the stick, exactly, that I fear. Well, maybe a little. What scares me is the syringe's testosterone injection cost australia It is a natural glycopeptide hormone made in the placenta of a pregnant woman, extracted from her urine, and purified into the Pregny — made by pharmaceutical giant Merck — loaded into my syringe.
The High Price of Low Testosterone | Men's Health Magazine Australia
One of the fastest growing areas in pharmacology today is testosterone supplementation in men. But while low-T is a genuine problem for some men, it's not as prevalent as you may think -- and the treatment is not without its risks. Here's what men need to know about testosterone replacement therapy, and why it should only be used when absolutely necessary. Art by Jim Cook Millions of American men currently use a prescription gel, patch, or injection to restore their testosterone levels to "normal.
Indeed, low levels of testosterone, also referred to as symptomatic androgen deficiency, or, colloquially, "andropause" yuck , is a serious problem for many men. It can cause disturbed sleep, declining muscle mass, low sex drive, and many other health problems. Many men see T-therapy as an indispensable and life-changing panacea. But research suggests it's less prevalent than you may realise -- and a growing body of evidence suggests it should not be prescribed lightly.
Testosterone is an androgen hormone and steroid that's primarily produced in the testicles of men. Smaller amounts are produced in both men and women by the adrenal glands, while women can also produce small amounts in their ovaries. Testosterone is necessary for puberty in boys and for the onset of adult characteristics in males, including facial hair, a larger penis, prominent body hair, a deep voice, and the Adam's apple.
It also plays an important physiological and psychological role by helping to produce sperm cells and by contributing to libido, energy, muscle strength, and immune function in both men and women.
To control the amount of testosterone that's produced, the brain's hypothalamus tells the pituitary gland how much to make. The pituitary gland then communicates this message by releasing hormones and chemicals, namely luteinizing hormone LH , into the bloodstream. Past the age of 30, however, most men experience a one-per cent decrease in testosterone production each year.
It's a part of ageing, but obesity and type 2 diabetes are also known to exacerbate the problem. There's disagreement among medical experts as to what constitutes a "healthy" level of testosterone for older men. Labs are known to vary reference numbers according to the average T-levels of young men, which can range anywhere from to nanograms per deciliter. It's also important to note that the level of T in a man's body changes throughout the day it's highest in the morning.
For men with problematically low levels, symptoms can influence mental, physical, and sexual performance. Here's what men should look out for a more detailed list is provided later in the article:. It's important to note, however, that having one, or even several of these symptoms is not an indication of low-T. Lab tests are required to make that determination more on that in a bit. If a patient has significant symptoms, he says, it may warrant a lab test.
But in most men, he notes, "the testosterone level is normal. A , published in the Journal of Clinical Endocrinology and Metabolism , pins a percentage to O'Leary's observation. Araujo monitored the testosterone levels of close to men between the ages of 30 and 79 years of age. Araujo notes that a more appropriate prevalence estimate should therefore also account for the presence of clinical symptoms. And when the researchers considered serum levels and clinical symptoms together, they got a much lower percentage:.
Crude prevalence of symptomatic androgen deficiency was 5. Prevalence was low in men less than 70 yr 3. Projection of these estimates to the year suggests that there will be as many as 6. It was only recently that medical experts came to the realisation that testosterone therapy can be used to treat low-T.
Previously, it was only applied to men with significant medical conditions, including exceedingly low levels of T or none at all. For example, it was used to treat Klinefelter's syndrome, a genetic disorder in which men carry an extra X chromosome. It was also used to treat men who lost both testicles to trauma or cancer, or who had surgery to remove tumours from the pituitary gland or hypothalamus which, as mentioned earlier, would have a serious impact on the brain's ability to send the chemical signal to the testicles to produce testosterone.
Today, T-therapy is used by millions of men to improve sexual desire, mood, energy, and sleep. It's also beneficial for bone health and can be used as a supplementary treatment for osteoporosis to increase bone density.
It can also be used to treat weak erections. Testosterone controls the production of nitric oxide, the chemical signal in the penis that initiates erections. It's also crucial for the maintenance of penile smooth muscle, which is responsible for control of blood flow into and out of the corpora cavernosa. Interestingly, T can be used as a treatment for erectile dysfunction ED if T levels are low, and it can also improve the response to Viagra in some men.
According to the FDA, 2. Testosterone replacement therapy is not without its risks. Though there is considerable disagreement over what those risks actually entail. Part of the problem is there hasn't been enough time to perform long-term clinical studies. What studies have been conducted often give contradictory results. For example, there's considerable debate as to whether T-therapy contributes to prostate cancer in men. The evidence is mixed. Back in , Harvard urology professor Abraham Morgentaler, an unabashed T-therapy proselytizer, penned a detailed report for Life Extension Magazine in which he sought to "destroy the myth" about T-replacement and prostate cancer.
For over sixty-five years, there has been a fear that testosterone therapy will cause new prostate cancers to arise or hidden ones to grow. Although no large-scale studies have yet been performed to provide a definitive verdict on the safety of testosterone therapy, it is quite remarkable to discover that the long-standing fear about testosterone and prostate cancer has little scientific support.
Morgentaler no longer fears that giving a man T-therapy will make a hidden prostate grow or increase his risk of developing prostate cancer. That's good news for their wives and partners, as well as for the men themselves. That said, a brand new study has shown that testosterone promotes prostate cancer in rats, a finding that " could signal public health risks for men using testosterone therapy. Regardless, many physicians are now refraining from prescribing T-therapy for men who are also being treated for active prostate cancer.
But most agree that it's safe under careful supervision for those who truly need it. There's also the link between T-therapy and cardiovascular problems. Some studies have found that men on T-therapy have few cardiovascular issues, while other studies point to the opposite. It appears that older men are particular vulnerable to heart attacks and elevated blood pressure.
And in fact, the Testosterone in Older Men study had to be halted once these findings became apparent. The men in this trial were an average age of 74 and were already diagnosed with high rates of chronic diseases like cardiovascular disease and diabetes. The problem is that T can increase hematocrit , the percentage of red blood cells in the bloodstream. When hematocrit gets too high, blood can become too thick, which can lead to a stroke or clotting events.
Though no scientific study has conclusively established a link between T-therapy and elevated hematocrit, doctors are wary about giving T to men who already have a high level of hematocrit. And as Pallais notes, there's the "testosterone trap" to consider: On treatment, the body stops making testosterone. Men can often feel a big difference when they stop therapy because their body's testosterone production has not yet recovered. As a result, this therapy could be exposing men to risks that could add up and become issues over time.
There are also short-term side-effects to consider, including acne, disturbed breathing while sleeping, breast swelling or tenderness, swelling in the ankles, and high red blood cell counts. In light of these risks, Endocrine Society's Clinical Practice Guidelines state that testosterone therapy should only be prescribed to men "who have unequivocally low levels of the hormone and decreased libido, erectile dysfunction or other symptoms of hypogonadism, a condition that results from low testosterone.
They say that testosterone therapy is suitable for men with symptomatic androgen deficiency to "induce and maintain secondary sex characteristics and to improve their sexual function, sense of well-being, muscle mass and strength, and bone mineral density. They put together this list of specific symptoms and signs indicating androgen deficiency in men:. Neither the popularity of T-Therapy nor the debate over its safety has gone unnoticed by the U.
Food and Drug Administration, which is now seriously considering the need for stricter controls for the use of T-therapy. Late last year, a joint FDA advisory committee examined the therapy and its potential association with cardiovascular therapy, among other burgeoning issues and abuses. That's crazy when you consider that over 2 million people were prescribed T-therapy in How these medicines work together in the body is not known.
After reviewing this and the mounting scientific evidence pointing to potential cardiovascular risks, the FDA voted to-1 to revise the labels of T drugs, including AbbVie's AndroGel and Lilly's Axiron to make it abundantly clear that the products should only be prescribed to men who seriously need it. Indeed, many men, including athletes both young and not-so-young , have been using T as way to counter ageing and boost performance.
Interestingly, and as noted by Bloomberg , these concerns are having an effect on sales. Looking ahead, the National Institutes of Health is sponsoring a short trial comparing men on T with those on a placebo.
These results should be quite interesting, as they will include information about sexual function and bone health. Keep all of this in mind the next time a TV ad tells you to "talk to your doctor about low-T. May 17, , 2: Google, apparently unsatisfied with the already incredibly long list of short-lived communications solutions that it has produced, is taking one more shot messaging. According to The Verge, the latest attempt is called Chat. Despite the fact they are flesh-eating guerilla warriors capable of thoroughly thrashing a vastly technologically superior foe, everyone's takeaway about the Ewoks is that they're cute, stress-lowering, fuzzy teddy bears.
Battlefront II has added a new mode that reminds us that these teddies can be utterly terrifying when you're their target. Want Gizmodo's email newsletter? Follow us, subscribe and get in touch! Don't have an account? Create one here Forgot your password? Click here to reset. Your email must be valid for account activation. Minimum of 8 standard keyboard characters. Subscriptions Email newsletters will contain a brief summary of our top stories, plus details of competitions and reader events.
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