Male Hormone Replacement (HRT): Testosterone and Hormone Deficiency in Men SymptomsMen in their mid-twenties and thirties enjoy their youth to the fullest. But, as they grow older, the changes in the body are sometimes depressing to many. Lack of replacemsnt, low sex drive, and fast aging are some of the signs which make one helpless. And, all this is usually due to shortage of hormones testosterones in men. However, Biology offered the power to alter and remove those defects from the body. Replaement replacement therapy hormone replacement therapy in men men is one of those miracles of science where men can refill their lost testosterone levels in the body. Many are aware of the side effects of this therapy as well.
Testosterone replacement: A cautionary tale - Harvard Health
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To find the most current information, please enter your topic of interest into our search box. June 18, -- Testosterone replacement therapy can help older men deficient in the hormone reduce their risks of heart disease , diabetes , and death, according to new research presented this week at ENDO 08, the annual meeting of The Endocrine Society.
Saad presented two of the studies at the meeting, held in San Francisco. Bayer Schering Pharma makes several testosterone products. Low levels of testosterone, he says, are associated with the metabolic syndrome -- a cluster of risk factors such as abnormal cholesterol and high blood pressure that boost risk of heart disease , stroke , and type 2 diabetes as well as other risks to health.
In the studies, Saad and his colleagues found that testosterone replacement therapy reduced the metabolic syndrome risk factors and did so in a similar way in all the age ranges studied.
In the first study, Saad's team looked at 95 men, aged 34 to 69, with low levels of testosterone. All had metabolic syndrome. Those who have this diagnosis must have three of five risk factors: Every three months, they measured cholesterol , waist circumference, and other parameters. The testosterone replacement was given as a long-acting injection, every three months.
The same product is not yet available in the U. The men were not given a special diet or exercise program. The supplemental testosterone reduced total cholesterol, "bad" LDL cholesterol , triglycerides , and body mass index while improving "good" HDL cholesterol.
The men lost their pot bellies, Saad says. We see a reduction by one-fourth to one-third of their total cholesterol. While hormone replacement therapy for women has been found to be associated with increased risks of heart disease and other problems, Saad doesn't foresee that will be the case with testosterone replacement.
In a second study, Saad divided the same 95 men into three groups, based on age: Prostate cancer is a slow-growing tumor. He also advises routine prostate checkups while on treatment. A test to monitor red blood cell formation, called a hematocrit, is needed, too. In excess, it can theoretically boost heart attack or stroke risk. Low testosterone levels are associated with an increased risk of death, according to Robin Haring, a researcher from the Institute for Community Medicine at Ernst-Moritz-Arndt University in Griefswald, Germany, who presented the finding at the meeting.
He evaluated data on nearly 2, men, aged 20 to 79, who participated in the Study of Health in Pomerania, following them for seven years until August He noted testosterone levels, age, weight , smoking habits, and physical activity.
The drugmaker Novo Nordisk partly funded the study. During the follow-up, men died. They were more likely to die of cardiovascular disease and cancer , but not of other causes.
Another researcher, Jane F. Reckelhoff, PhD, professor of physiology and biophysics at the University of Mississippi Medical Center in Jackson, offers a caveat about supplemental testosterone: The safety studies have not been done and they need to be done.
She reviewed the studies for WebMD and has published on a review about testosterone supplements for the American Journal of Physiology Renal Physiology. He agrees close monitoring of men on testosterone is needed. Testosterone Replacement Therapy and Heart Disease Risks In the first study, Saad's team looked at 95 men, aged 34 to 69, with low levels of testosterone. Continued Testosterone Replacement Therapy: Test Results "We saw a consistent improvement of the parameters of metabolic syndrome," Saad says.
They found the older men and the younger men had similar improvement in their risk factors. Continued Testosterone and Death Risk Low testosterone levels are associated with an increased risk of death, according to Robin Haring, a researcher from the Institute for Community Medicine at Ernst-Moritz-Arndt University in Griefswald, Germany, who presented the finding at the meeting.
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