Only certain patients have access to the cannabis-based oil under Texas' CBD oil is derived from the cannabis plant, also known as marijuana. called “ intractable” epilepsy—meaning at least two other medications have. He is director of NYU Langone's Comprehensive Epilepsy Center in marijuana is legal would see the same effects in CBD oil produced by. Epileptic seizures are caused by irregular electrical discharges, or misfiring, among brain Medical cannabis has anticonvulsant properties.
CBD Anti-seizure Tinctures of Properties
For example, some human clinical trials suggest that CBD could be effective in treating symptoms of anxiety, particularly social anxiety, Bonn-Miller said. This is the potential use for CBD with the most evidence after usefulness in epilepsy, but "there's a decent gap between those two," he said. CBD's usefulness as an anti-inflammatory medication is the next most promising, but those results come mostly from animal studies, experts said. The rest of the potential uses -- as an antipsychotic, antidepressant or sleep aid "have all been studied in animals, with only one or two examples of studies in humans," Bonn-Miller said.
And Welty said the studies that have featured humans for these other CBD uses have either been case reports or studies that did not compare results against a control group that did not use the oil.
There also are concerns about both the quality of CBD oil being produced and its potential side effects, the experts added. States are struggling to put regulations in place, but they don't have the deep pockets of the federal government.
Meanwhile, a study led by Bonn-Miller found that nearly 7 of 10 CBD products didn't contain the amount of marijuana extract promised on the label. Nearly 43 percent of the products contained too little CBD, while about 26 percent contained too much, Bonn-Miller said.
If it isn't made in the right way, you may not be getting much drug into your systemic circulation. It can actually make seizures worse. Those are the sorts of things you need to be careful about," Bonn-Miller said.
For example, epilepsy studies found that "there were very clearly increases in the blood levels of some other anti-epileptic drugs when people were on CBD," Welty said.
This could mean that people taking anti-epilepsy drugs alongside CBD will need to adjust their dosage downward to avoid side effects, Welty noted. There also is some indication that CBD might harm the liver. About 10 percent of people taking CBD in studies had increases in liver enzymes, which would indicate possible liver damage, Welty said.
Welty recommends that people interested in CBD seek out a doctor who has read up on the extract and its potential uses. The researchers noted that CBD reduced some symptoms associated with substance use disorders. These included anxiety , mood-related symptoms, pain, and insomnia. More research is necessary, but these findings suggest that CBD may help to prevent or reduce withdrawal symptoms.
After researching the safety and effectiveness of CBD oil for treating epilepsy, the FDA approved the use of CBD Epidiolex as a therapy for two rare conditions characterized by epileptic seizures in The types of seizures that characterize LGS or DS are difficult to control with other types of medication. The FDA specified that doctors could not prescribe Epidiolex for children younger than 2 years. A physician or pharmacist will determine the right dosage based on body weight. Authors of a review noted that CBD has anti-seizure properties and a low risk of side effects for people with epilepsy.
Findings suggested that CBD may also treat many complications linked to epilepsy, such as neurodegeneration, neuronal injury, and psychiatric diseases. Another study, published in Current Pharmaceutical Design, found that CBD may produce effects similar to those of certain antipsychotic drugs, and that the compound may provide a safe and effective treatment for people with schizophrenia.
However, further research is necessary. Some researchers have found that CBD may prove to combat cancer. Authors of a review published in the British Journal of Clinical Pharmacology found evidence that CBD significantly helped to prevent the spread of cancer. The researchers also noted that the compound tends to suppress the growth of cancer cells and promote their destruction.
They pointed out that CBD has low levels of toxicity. They called for further research into its potential as an accompaniment to standard cancer treatments. Doctors often advise people with chronic anxiety to avoid cannabis, as THC can trigger or amplify feelings of anxiousness and paranoia.
However, authors of a review from Neurotherapeutics found that CBD may help to reduce anxiety in people with certain related disorders. According to the review, CBD may reduce anxiety-related behaviors in people with conditions such as:. The authors noted that current treatments for these disorders can lead to additional symptoms and side effects, which can cause some people to stop taking them.
No further definitive evidence currently links CBD to adverse effects, and the authors called for further studies of the compound as a treatment for anxiety. Type 1 diabetes results from inflammation that occurs when the immune system attacks cells in the pancreas. Research published in by Clinical Hemorheology and Microcirculation found that CBD may ease this inflammation in the pancreas.
This may be the first step in finding a CBD-based treatment for type 1 diabetes. A paper presented in the same year in Lisbon, Portugal, suggested that CBD may reduce inflammation and protect against or delay the development of type 1 diabetes.
Acne treatment is another promising use for CBD. The condition is caused, in part, by inflammation and overworked sebaceous glands in the body. A study published by the Journal of Clinical Investigation found that CBD helps to lower the production of sebum that leads to acne, partly because of its anti-inflammatory effect on the body.
Sebum is an oily substance, and overproduction can cause acne. Initial research published in the Journal of Alzheimer's Disease found that CBD was able to prevent the development of social recognition deficit in participants. This means that CBD could help people in the early stages of Alzheimer's to keep the ability to recognize the faces of people that they know. This is the first evidence that CBD may slow the progression of Alzheimer's disease.
Cannabis is legal for either medicinal or recreational use in some American states. Other states have approved the use of CBD oil as a hemp product but not the general use of medical marijuana. Some state and federal laws differ, and current marijuana and CBD legislation in the U. There is an ever-changing number of states that do not necessarily consider marijuana to be legal but have laws directly related to CBD oil. The following information is accurate as of May 8, , but the laws change frequently.
However, state legislators generally approve the use of CBD oil at various concentrations to treat a range of epileptic conditions. A full list of states that have CBD-specific laws is available here. Different states also require different levels of prescription to possess and use CBD oil. In Missouri, for example, a person can use CBD of a particular composition if they can show that three other treatment options have failed to treat their epilepsy.
Anyone considering CBD oil should speak with a local healthcare provider. They can provide information about safe CBD sources and local laws surrounding usage. This is one of more than 80 active chemicals in marijuana. The new product was approved to treat seizures associated with two rare, severe forms of epilepsy in patients two years of age and older. Many small-scale studies have looked into the safety of CBD in adults.
They concluded that adults tend to tolerate a wide range of doses well. Researchers have found no significant side effects on the central nervous system , the vital signs, or mood, even among people who used high dosages. The most common side effect was tiredness. Also, some people reported diarrhea and changes in appetite or weight.
Concerning the product that the FDA approved to treat two types of epilepsy, researchers noticed following adverse effects in clinical trials:. The patient information leaflet notes that there is a risk of worsening depression or suicidal thoughts. It is important to monitor anyone who is using this drug for signs of mood change. Research suggests that a person taking the product is unlikely to form a dependency.
There is often a lack of evidence regarding the safety of new or alternative treatment options. Usually, researchers have not performed the full array of tests. Anyone who is considering using CBD should talk to a qualified healthcare practitioner beforehand.
When drugs do not have FDA approval, it can be difficult to know whether a product contains a safe or effective level of CBD. Unapproved products may not have the properties or contents stated on the packaging. It is important to note that researchers have linked marijuana use during pregnancy to impairments in the fetal development of neurons. Regular use among teens is associated with issues concerning memory, behavior, and intelligence. CBD-based products come in many forms. Some can be mixed into different foods or drinks or taken with a pipette or dropper.
Others are available in capsules or as a thick paste to be massaged into the skin. Some products are available as sprays to be administered under the tongue. Recommended dosages vary between individuals, and depend on factors such as body weight, the concentration of the product, and the health issue. Due to the lack of FDA regulation for most CBD products, seek advice from a medical professional before determining the best dosage. As regulation in the U. After discussing dosages and risks with a doctor, and researching regional local laws, it is important to compare different brands of CBD oil.
There is a selection of CBD products available for purchase online. CBD has been tested and approved for one specific use.
Does this mean it is safe and will soon have approval for other uses? The research is emerging to support the use of CBD for numerous conditions, as well as looking closely at safety, side effects, and long-term effects.
There are some valid concerns about long-term use that must be tested before CBD can be recommended for other diseases. As one approach to pain management, it is seen as an alternative option to the addicting narcotics. The use of CBD oil might complement a medical approach to treating physical and mental diseases.
It is worth discussing with your doctor. We picked linked items based on the quality of products, and list the pros and cons of each to help you determine which will work best for you. We partner with some of the companies that sell these products, which means Healthline UK and our partners may receive a portion of revenues if you make a purchase using a link s above.
Article last updated by Yvette Brazier on Fri 27 July All references are available in the References tab. Cannabidiol as a potential treatment for anxiety disorders. Neurotherapeutics, 12 4 , — Long-term cannabidiol treatment prevents the development of social recognition memory deficits in Alzheimer's disease transgenic mice [Abstract]. Journal of Alzheimer's Disease, 42 4 , 1,—1, Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders.
Epilepsia, 55 6 , — An updated review of the research on the risks and harms associated to the use of marijuana. Highlights of prescribing information: Early phase in the development of cannabidiol as a treatment for addiction: Opioid relapse takes initial center stage. Experimental cannabidiol treatment reduces early pancreatic inflammation in type 1 diabetes [Abstract].
CBD Oil: All the Rage, But Is It Really Safe and Effective?
The FDA recently approved the use of Epidiolex (a plant-based formulation of CBD) to treat seizures for people 2 years of age and older with Dravet syndrome . CBD oil may offer a range of benefits, including reducing pain and Authors of a review noted that CBD has anti-seizure properties and a. Over the years, a number of high profile cases have raised awareness of CBD's anti-seizure properties, but it's only recently that science has.