It's known as the Endocannabinoid System, and it is the catalyst behind the many benefits CBD. To understand how CBD works and to fully. 60 Second Summary. Recent science has found that the endocannabinoid system does not just respond to the endocannabinoids produced in the body, but . Cannabinoid science. Medical marijuana research led to the discovery of The Endocannabinoid System, an important system in the human body.
endocannabinoid system and the CBD
Keep in mind that this CBD benefits chart is not a full list, and we are only beginning to discover how cannabinoids can help and heal. To date, experts agree there are two types of cannabinoid receptors; cannabinoid receptor type 1 CB1 and cannabinoid receptor type 2 CB2. These neurons act as a sort of lock, with cannabinoids acting as the key. Although they have similar sounding names, these two receptors perform very different functions in the human body.
CB1 receptors first discovered in exist in high numbers in the brain especially the hypothalamus, hippocampus, and amygdala , central nervous system CNS , intestines, connective tissues, gonads, and various other glands. While these are desirable effects for most people, CB1 receptor activation does not come without risks.
Please note that these are most often side effects associated with chronic consumption of a potent CB1 receptor agonist such as THC, and not with a non-psychoactive substance such as CBD. CB2 receptors first discovered in occur most commonly in the spleen, tonsils, thymus, and immune cells such as mast cells, monocytes, macrophages, B and T cells, and microglia; only a small number exist in the brain. Changes in CB2 receptor function is synonymous with virtually every type of human disease; be it cardiovascular, gastrointestinal, neurodegenerative, psychiatric, and autoimmune.
It even plays a role in liver and kidney function, bone and skin health, cancer, and even pain-related illnesses. The human body does produce cannabinoids. Endogenous Cannabinoids are neurotransmitters produced within our bodies that bind to cannabinoid receptors in the brain, immune system, and elsewhere.
Endocannabinoids perform differently to the more well-known neurotransmitters like serotonin, dopamine, and norepinephrine. Dopamine, for example, is synthesized in advance, stored in the vesicle, and in response to stimuli, is released from the presynaptic cell, where it crosses the synapse, lands on the postsynaptic cell, and causes activation.
Endocannabinoids, on the other hand, are key components of cellular membranes that we manufacture on demand. Since endocannabinoids are hydrophobic, they cannot travel very far in the body and so their effects are localized. After several decades of research, scientists studying the effects of marijuana made several important discoveries. Not only did they identify the active ingredient in marijuana, they also discovered where and how it works in the brain—via a new system they called the endocannabinoid EC system.
The EC system—named after the marijuana plant Cannabis sativa and its active ingredient deltatetrahydrocannabinol THC —is a unique communications system in the brain and body that affects many important functions, including how a person feels, moves, and reacts.
The natural chemicals produced by the body that interact within the EC system are called cannabinoids, and like THC, they interact with receptors to regulate these important body functions. Review Figure 1 and the steps below to take a closer look at the components of the EC system, how it works, and the effects of THC. Typically, the chemicals called neurotransmitters are released from a neuron a presynaptic cell , travel across a small gap the synapse , and then attach to specific receptors located on a nearby neuron postsynaptic cell.
This spurs the receiving neuron into action, triggering a set of events that allows the message to be passed along. We understand the results of this system not functioning properly so we take measures to make sure to regulate our blood pressure, mind our salt intake, and enter into a daily regimen of exercise and proper nutrition. This practice keeps the circulatory system well-balanced. We already know that. Allow me to introduce to you the one system you might not know or understand — the endocannabinoid system.
It really is quite remarkable. These are known as endocannabinoids. Cannabinoid receptors are known to be the most abundant G-protein neuroreceptors in the brain and throughout the rest of your body. G-proteins are important because they help the body stimulate other systems, acting as molecular switches inside of your cells.
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Most people have heard an earful about the health benefits of CBD — its It's now clear that the endocannabinoid system (ECS) evolved. The endocannabinoid system is involved in a host of homeostatic and .. Chronic NP pain, 34, THC+CBD , Oral mucosal, variable dose. What is the endocannabinoid system? Your endocannabinoid system (ECS) is responsible for keeping all of your other bodily systems in.