Both THC & CBD interact with cannabinoid receptors, but the types of effects brought about by these compounds couldn't be more different. There's a lot of confusion about the difference between the different components of the cannabis plant, especially with current laws. We'll take a look at two. The Difference Between CBD and THC. If you didn't already know — CBD and THC have the exact same chemical makeup: 21 carbon atoms.
THC? CBD and between What the Differences Are
In general, marijuana plants are carefully cultivated with the intent of maximizing their concentration of THC. Twenty-nine states and the District of Columbia , however, have passed their own laws permitting the use of medical marijuana containing THC if a licensed physician recommends it.
Eight of those states and the District of Columbia have gone a step further and passed laws permitting marijuana with THC for personal use. CBD oil made from marijuana is prohibited federally, but CBD hemp oil products are legal under federal law. Some states have passed their own policies regulating CBD or hemp, but more often than not, hemp derived CBD is legally accessible in the U. CBD is considered an indirect antagonist of cannabinoid agonists. You can learn even more about CBD and THC, as well as and what research has found about their therapeutic potential, by visiting our education page.
Federal Tax ID The information contained in this website is for general information and educational purposes only. It does not constitute medical advice. Known as phytocannabinoids , these compounds interact with CB1 and CB2 receptors found in the endocannabinoid system present in all mammalian species.
THC and CBD are just two compounds from a family of around bi- and tri-cyclic compounds cannabinoid compounds found naturally in cannabis. Structurally, however, there is one important difference. It is this seemingly small difference in molecular structure that gives the two compounds entirely different pharmacological properties. As with many of the cannabinoids, THC and CBD have low solubility in water, but good solubility in most organic solvents, particularly lipids and alcohols.
Both THC and CBD are present in cannabis in a mixture of acidic forms, which are readily de-carboxylated and chemically altered upon heating, important when you consider that smoking cannabis is the most common form of consumption.
THC is also well known for its ability to bind to glass and plastic. Therefore, THC preparations are typically stored in basic or organic solvents in amber silicate glassware to avoid loss, especially during analytical testing procedures.
THC is a potent partial agonist of CB1. It is this stimulation which leads to the major psychotropic effects of cannabis consumption. CB1 is a G protein-coupled cannabinoid receptor located primarily in the central and peripheral nervous system with a particularly high abundance in the brain.
As part of the endocannabinoid system it is activated by the endogenous neurotransmitters, anandamide and 2-arachidonoylglycerol, as well as other naturally occurring compounds including the phytocannabinoids found in cannabis. As a potent partial agonist of CB1, THC stimulates the CB1 receptor leading to the psychotropic effects experienced when consuming cannabis.
CBD on the other hand, is classified as a negative allosteric modulator of CB1, meaning it effectively alters the shape of the CB1 receptor. Through its interactions with the CB1 receptor, CBD is thought to modulate the psychotropic effects of THC by inhibiting its ability to bind to and stimulate the receptor. CBD is able to reduce some of the negative effects of THC by decreasing anxiety, paranoia and the short-term memory impairment often experienced when consuming cannabis.
Evidence suggests that a CBD-rich product with little THC can in fact convey therapeutic benefits without having a euphoric or dysphoric effect.
In broad terms, this reflects the consensus of the traditional pharmaceutical industry that a drug with a single active ingredient is easier to develop, test, produce, prescribe and regulate.
Here's your guide to all things cannabis, including THC vs CBD, the difference between marijuana and hemp plants, and what cannabinoids. Congress quietly passed a hemp law that has people wondering about the difference between CBD and THC. Here's what you need to know. Have questions about cannabis? Here's your guide to hemp oil, CBD oil, and all the different cannabinoids.