Tutorial contains images and text for pathology education. change of liver, gross [CT] · Micronodular cirrhosis and fatty change of liver, gross · Cirrhosis of liver. Tutorial contains images and text for pathology education. Recall normal liver anatomy and histology. • 2. Understand basic terminology/ definitions. • Apoptosis, cholestasis, limiting plate, interface.
This has functional significance as more oxygenated blood flows from the zone 1 and becomes less oxygenated as it flows through zone 2 and zone 3. The hepatic parenchyma consists of cords of hepatocytes arranged in single-cell layer which is separated from other hepatic cords by vascular sinusoids. The arrangement and organization of liver cell plates is largely determined by the network of vascular sinusoids. Note the presence of red blood cells running through sinusoids.
In passive liver congestion due to right heart failure or hepatic vein thrombosis the sinusoids can be markedly dilated with pooling blood unable to move forward. The hepatocytes are arranged in a single cell cord or plate and joined to each other by cellular junctions enclosing small bile canaliculi.
Each hepatocyte is a polygonal cell with a small round nucleus and abundant pink finely granular cytoplasm. Bile formed by hepatocytes exits through exocytosis into small tubular spaces between adjacent hepatocytes, the so-called bile canaliculi. Note the presence of very small round to oval canalicular spaces in the middle of cell junctions four thin arrows. The vascular sinusoids are lined by a fenestrated endothelial layer curved arrow not supported by a basal lamina.
Resident macrophages adhered to the lining endothelial layer in the sinusoids are known as Kupffer cells arrowhead and have phagocytic functions like all other cells of the mononuclear phagocytic system. The single-cell layer hepatic organization is best appreciated by histochemical staining for reticulin. The scant extra-sinusoidal space between fenestrated endothelial layer and hepatocyte surface facing sinusoids, known as space of Disse, contains primarily collagen type III fibers of reticulin admixed with smaller amounts of type 1, type IV, V, VI, and XVIII collagen fibers.
The staining for reticulin arrowheads is thus very helpful in delineating the architecture of hepatic plates and any abnormality thereof.
A reticulin stain is very helpful in the diagnosis of well differentiated hepatocellular carcinoma where cells are arranged in more than two-cell-thick plates. The space of Disse also contains small amounts of type I collagen which is highlighted as blue by trichrome staining arrow. Any abnormal pericellular, portal, and periportal collagen I deposition is easily highlighted by trichrome stain.
The bile canalicular system serves to collect bile draining from hepatocytes and forms a vast network which drains bile into the portal bile duct on its way to extrahepatic bile duct.
The bile canalicular lattice can be highlighted by staining for polyclonal CEA which shows canaliculi running between adjacent hepatocytes like water canals arrow. The bile canalicular network can also be highlighted by staining for CD This fortuitous image shows a section right through the plane of canaliculi running in horizontal direction between adjacent hepatocytes. This image shows bile canaliculi in a different plane running vertically arrows.
If you would like to know more, you can view our privacy statement here. This year our two annual courses will be linked to provide a two-day course of lectures and practical experience in liver pathology. Delegates have the option of attending either or both of the days. Registration is via the RCPath website. This course, organised by Prof. Presentations by hepatologists and histopathologists cover the investigation of medical liver diseases.
The course provides a practical diagnostic approach to reporting medical liver biopsies, focusing on the importance of clinico-pathological correlation in assessing common patterns of liver damage. The programme can be viewed here. The histology for cases presented in the afternoon can be pre-viewed via the on line digital slides - most delegates have done this and found it useful.
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li Herpes group (Cytomegalovirus, Herpes simplex, Varicella/Zoster, Epstein- Barr). li Other viruses rarely affecting the liver (Adenoviruses, Coxsackie. Liver Pathology: Cirrhosis, Hepatitis, and Primary Liver Tumors. Update and Diagnostic Problems. Linda Ferrell M.D.. Modern Pathology. Histology of the Liver. Looking at a section of liver is somewhat reminiscent of looking down out of an airplane at a suburban neighborhood. One sees a very.