The typical dose used in the studies of saffron versus Alzheimer's, so 30mg should be about 13 threads (which is typicallty how it's sold in the. Saffron (Crocus sativus), is the world’s most expensive spice. These studies show that saffron, at the recommended dose, has antidepressant properties comparable to the reference drugs. Using saffron in food will provide the same effects as supplementation, since saffron. This thread is for sharing your dosages of CBD that helped you overcome Anxiety **Official Anxiety* Dosage Thread** *Please note.
Crocus sativus of the family iridaceae is a spice commonly referred to as saffron, which is derived from the arabic word za-faran meaning "be yellow"  and a previous name for it pre-Grecian was Krokos. Its production is usually labour intensive, with saffron production thought to total kg annually and anywhere between ,, flowers and hours of labor to produce 1kg of dried stigma the main component of the spice used , due in part to only three stigma existing in one plant and each weighing only 2mg.
Safranol and hydroxysafranol, which are monoterpene aldehydes which result in the characteristic aroma and taste of saffron  and are lysed from the picrocrocin molecule after heat treatment. Crocin molecules, which are water soluble carotenoids.
Different variations of crocin ie. Crocins in saffron are thought to hinder 5-HT 2C signalling due to antagonizing the effects of m-Chlorophenylpiperazine mCPP , a serotonin receptor agonist,  in a rat model.
Supplementation of saffron stigma A meta-analysis on the usage of saffron on depressive symptoms  against either placebo or antidepressant reference drugs found that the usage of saffron supplementation in five trials at 30mg noted that saffron was more effective than placebo in two studies   although the studies comparing it to reference drugs imiprazole and fluoxetine failed to find a significant difference in efficacy although saffron appeared to be associated with less side-effects.
Two studies, one in men and one in women, have found that saffron as an ajuvant to fluoxetine may alleviate the sexual dysfunction related to floxetine treatment while having no additional effects on its antidepressive action. Crocins from saffron could be beneficial for OCD, as crocins are able to reverse a chemically-induced model of OCD in rats.
Due to its potential anti-inflammatory properties, saffron has been investigated in humans for the prevention of delayed-onset muscle soreness DOMS. Over 10 days, 39 non-active college students took either mg dried saffron, 75 mg 25 mg thrice daily indomethacin an NSAID , or placebo.
The saffron group maintained the maximum isotonic and isometric force they could exert hours after the exercise, while the placebo group's performance was reduced, and the saffron group outperformed the indomethacin group 72 hours after the exercises.
Plasma creatine kinase and lactate dehydrogenase levels indicators of muscle damage were also reduced in the saffron group compared to placebo at hours; the indomethacin group was similar at hours after exercise, but was more similar to placebo at 24 hours.
Perceived pain in the saffron group was also similar to indomethacin; both groups had an average pain perception close to 0 on a 6-point scale after 48 and 72 hours, while the placebo group had a rating of around 3 to 4. At 24 hours after exercise, saffron outperformed indomethacin; the saffron group had a perceived pain rating of about 0.
Supplementation of mg saffron extract crude powder of the stigma in healthy men once daily for three weeks increased serum IgG concentrations Total lymphocytes including T and B cells are not affected following supplementation of mg crude saffron extract in otherwise healthy men over six weeks relative to placebo. Saffron as aromatherapy 20 minutes of exposure in otherwise healthy women appears to cause a mild increase in estradiol concentrations in saliva in both the luteal and follicular phases relative to baseline.
Saffron as aromatherapy 20 minutes of exposure in otherwise healthy women does not appear to significantly influence testosterone concentrations  and supplementation of saffron at 60mg 30mg twice daily over the course of 26 weeks in infertile men has failed to modify circulating testosterone concentrations relative to placebo.
Saffron as aromatherapy 20 minutes of exposure in otherwise healthy women appears to cause a reduction in cortisol from approximately 1. Crocetin appears to be able to bind to DNA and form adducts in various cancerous lines HeLa, A, and VA in vitro  while crocetin and other compounds derived from saffron dihydrocrocetin and safranal also have this property in normal cells,  with the binding constants in normal cells being in the range of Saffron has been tested for its ability to prevent or attenuate SSRI-related sexual dysfunction, in part due to its ability to increase measures of libido in male rats, a property traced back to saffron's crocin content, but not its safranal content.
In women who benefitted from SSRI therapy for depression but reported sexual dysfunction, supplementation of 15mg saffron stigma extract twice daily 3. A small pilot study investigating the effects of saffron on men with erectile dysfunction found benefits with supplementation for 10 days with a high dose of saffron mg daily  although a later and larger study also assessing erectile dysfunction in men using 15mg of the petal extract twice daily for four weeks failed to note any improvement on the same rating scale IIEF or other self-reported measures of erectile function.
One uncontrolled study assessing the effects of saffron on male seminal parameters noted that, when given 50mg of saffron in milk thrice a week, seminal motility and morphology improved without any alterations in sperm count. The pathogenesis of asthma involves many inflammatory mediators. Serum histamine levels and some types of white blood cell WBC counts were also improved, although only safranal lowered total WBC count. Saffron has been tested for its retinal protective properties as this is a function common to many carotenoids astaxanthin and lutein and the crocins have been implicated in similar protective effects.
In patients with age-related macular degeneration AMD , supplementation of 20mg saffron for three months increased the amplitude of focal electroretinograms fERGs, which assesses cone sensitivity in early AMD  and reduced thresholds relative to baseline and placebo, which is suggestive of improvements in eye function; ophthalmoscopic appearance was unchanged, however.
A human study failed to find carryover effects of saffron carotenoids through a crossover design, which suggests that, unlike other carotenoids, there is not a significant buildup of saffron carotenoids with supplementation, perhaps because saffron carotenoids are water-soluble, which is atypical for carotenoids. A week trial in people with mild to moderate Alzheimer's disease given 15mg saffron extract twice daily once daily for the first four weeks relative to the reference drug of 5mg donpezil twice daily and assessed by a variety of measurement scales on cognition MMSE, ADAS-cog, and CDR-SB found that although there was no difference found between the saffron and donpezil arms, both groups failed to show significant changes on ADAS-cog and CDR-SB from their baselines.
Supplementation of saffron at doses higher than normal mg in humans has been associated with some alterations in blood and hemodynamic parameters that, while statistically significant, where not of large enough magnitude to be considered adverse, although abnormal uterine bleeding was found in two women at doses of mg. More prolonged supplementation 26 weeks with 60mg saffron daily in men was associated with reductions in red and white blood cell counts as well as platelets, along with a drop in systolic and diastolic blood pressure of This page is regularly updated, to include the most recently available clinical trial evidence.
History Research analysis by Kamal Patel and verified by the Examine. Last updated on Jun 14, Free 5 day supplement course. Also Known As Crocus sativus Do Not Confuse With Turmeric Indian saffron Things to Note Due to traditional usage as an abortifacient and infrequent reports of irregular vaginal bleeding at higher doses mg of saffron, it may be prudent to avoid supplementation during pregnancy Chronic usage of saffron over eight weeks continuous should be approached cautiously, as double the recommended dose may result in harm to the body.
Grade Level of Evidence Robust research conducted with repeated double-blind clinical trials Multiple studies where at least two are double-blind and placebo controlled Single double-blind study or multiple cohort studies Uncontrolled or observational studies only.
The amount of high quality evidence. The more evidence, the more we can trust the results. The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect. Scientific research does not always agree. Basophil count has been noted to mildly decrease following saffron supplementation alongside a reduction in IgM concentrations.
A decrease in blood pressure was noted in otherwise healthy normotensive men following 26 weeks of saffron supplementation at 60mg daily, although this was thought to possibly be related to chronic toxicity of the higher than normal dose. The aroma of saffron has been noted to reduce cortisol concentrations to a mild degree in otherwise healthy women, and this occurred alongside a reduction in state anxiety.
The aroma of saffron appears to cause a mild increase in circulating estrogen concentrations in otherwise healthy women following 20 minutes of exposure. Secondary to reducing snacking thought to be via increasing satiety from meals saffron appears to reduce overall food intake. Hemoglobin has been noted to be decreased in one study and thought to be related to possible toxic effects of moderately high dose saffron 60mg for more than 8 weeks.
An increase in IgG concentrations has been noted to occur with saffron supplementation alongside a decrease in IgM and no influence on IgA. A decrease in IgM concentrations has been noted to occur following supplementation of saffron. Supplementation of saffron appears to be able to cause a mild increase in monocyte concentrations in serum. A decrease in RBCs has been noted in one study suggesting saffron toxicity with prolonged supplementation of a double dose 60mg.
Supplementation of 60mg saffron was able to reduce platelet counts in serum following eight weeks of exposure increasing in magnitude until study cessation at 26 weeks thought to be related to toxicity. SSRI related sexual dysfunction in both men and women appears to be reduced with coingestion of saffron, although saffron does not alter the efficacy of SSRI therapy on depression.
Mixed evidence on the efficacy of saffron, but it is possible that supplementation could delay an increase in symptoms without a therapeutic effect. Supplementation of saffron appears to increase visual acuity in persons with age-related macular degeneration. A reduction in weight has been noted to a very mild degree which may be wholly related to a reduction in snacking that has been observed with saffron supplementation in overweight women.
In the case of levonorgestrel , there are no specific foods that you must exclude from your diet when receiving this medication. Tell your doctor about all of the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Call your healthcare provider right away if you think you are pregnant. If you get pregnant while using this medication, you may have an ectopic pregnancy.
This means that the pregnancy is not in the uterus. Unusual vaginal bleeding or abdominal pain may be a sign of ectopic pregnancy. Ectopic pregnancy is a medical emergency that often requires surgery. Ectopic pregnancy can cause internal bleeding, infertility, and even death. There are also risks if you get pregnant while using this medication and the pregnancy is in the uterus.
Severe infection, miscarriage, premature delivery, and even death can occur with pregnancies that continue with an intrauterine device IUD. Because of this, your healthcare provider may try to remove the IUD, even though removing it may cause a miscarriage. If the IUD cannot be removed, talk with your healthcare provider about the benefits and risks of continuing the pregnancy. If you continue your pregnancy, see your healthcare provider regularly.
Call your healthcare provider right away if you get flu-like symptoms, fever, chills, cramping, pain, bleeding, vaginal discharge, or fluid leaking from your vagina.
These may be signs of infection. It is not known if this hormone-releasing system can cause long-term effects on the fetus if it stays in place during a pregnancy. Levonorgestrel has been detected in human breast milk. Because of the possibility for adverse reactions in nursing infants from levonorgestrel, a choice should be made whether to stop nursing or to stop the use of this medication.
The importance of the drug to the mother should be considered. First, your healthcare provider will examine your pelvis to find the exact position of your uterus.
Your healthcare provider will then clean your vagina and cervix with an antiseptic solution, and slide a thin plastic tube containing the intrauterine device IUD into your uterus. Your healthcare provider will then remove the plastic tube, and leave the IUD in your uterus. Your healthcare provider will cut the threads to the right length. Placement takes only a few minutes during an office visit. You may experience pain, bleeding or dizziness during and after placement.
If these symptoms do not pass 30 minutes after placement, the IUD may not have been placed correctly. Your healthcare provider will examine you to see if the IUD needs to be removed or replaced.
You should check that the IUD is in proper position by feeling the removal threads. You should do this after each menstrual period. First, wash your hands with soap and water. Feel for the threads at the top of your vagina with your clean fingers.
The threads are the only part of the IUD you should feel when it is in your uterus. Be careful not to pull on the threads. If you feel more than just the threads, the IUD is not in the right position and may not prevent pregnancy.
Call your healthcare provider to have it removed. If you cannot feel the threads at all, ask your healthcare provider to check the IUD is still in the right place. In either case, use a non-hormonal birth control method such as condoms or spermicide until otherwise advised by your healthcare provider.
Call your healthcare provider if you have any questions or concerns. Otherwise, you should return to your healthcare provider for a follow-up visit 4 to 12 weeks after the IUD is placed to make sure that it is in the right position. Call your healthcare provider if you have any concerns about this medication.
Be sure to call if you:. However, if an overdose is suspected, seek emergency medical attention. Otherwise, you should return to your healthcare provider for a follow-up visit 4 to 6 weeks after levonorgestrel intrauterine device IUD is inserted to make sure that it is in the right position. It may be removed by your healthcare provider at any time.
Levonorgestrel Intrauterine Device Overview Reviewed: How was your experience with? First, a little about yourself Male Female. What tips would you provide a friend before taking? How well did work for you?
Did you experience many side effects while taking this drug? How likely would you be to recommend to a friend? Levonorgestrel Intrauterine Device may be found in some form under the following brand names: Levonorgestrel Intrauterine Device is part of the drug class: Common side effects of levonorgestrel include: Pain, bleeding or dizziness during and after placement. If these symptoms do not stop 30 minutes after placement, the IUD may not have been placed correctly. The IUD may come out by itself.
This is called expulsion. You may become pregnant if the IUD comes out. If you notice the IUD has come out, use a backup birth control method like condoms and call your healthcare provider. About 2 out of 10 women stop having periods after 1 year of levonorgestrel use.
Skyla IUD Dosage
Med Radiol (Mosk). Mar;14(3) [Use of the TsVM, BESM-3M and "MIR" computers in calculating dosage distribution for nylon threads with Co Learn more about Saffron uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain Saffron. It is just absolutely hilarious how blindly mad people get when they don't realize it's a joke, and even when I explain it is a joke they still get.