Jul 8, I wanted to find out more about the weed-arthritis connection, so I figured that the best way to start is to learn all I possibly can about arthritis. Jul 31, The same study noted other possible benefits of cannabinoids via suppression of Poor Prognostic Factors in Rheumatoid Arthritis May Not Affect The Health Effects of Cannabis and Cannabinoids: The Current State of. Can medical marijuana help your arthritis pain? unearthed nearly 2, more recent scientific papers on marijuana—with 6 While cannabis can be ingested, most prefer to inhale it, raising the issue of adverse effects on the respiratory.
Studies on Arthritis Recent on Cannabis’ Effect
Efficacy of transdermal CBD for reduction in inflammation-associated symptoms in adjuvant-induced monoarthritic animals was determined comparing knee joint circumference and other features. Likewise, increased synovial membrane thickness was reduced by the 6. These results concur with previous studies showing orally administered CBD decreased inflammation Malfait et al.
Decreased inflammation and reduction in secretions of pro-inflammatory and matrix-degrading effector molecules by the synovial cell connective tissue membrane lining the joints are important for symptomatic treatment of patients with rheumatoid arthritis. Pro-inflammatory and matrix-degrading effector molecules produced in excess are primary contributors to cartilage degradation over time Ospelt et al.
The improvement of pain scores provided by transdermal CBD is an indirect measure of joint inflammation and direct measure of function. The PWL in response to noxious heat stimuli was optimal with both the 6. Analogous to the results presented here, the highest dose of CBD administered in that study also did not perform as well as the next lower dose. In the same study at 6 h post inflammation, CBD treatment with two orally administered lower doses, 5 and 7. Peripheral inflammation and hypersensitivity are reversed by pharmacological inactivation of both central and peripheral neurons and central microglia Sluka et al.
Although CBD is described as an attenuator of both mechanical and heat hypersensitivity induced by inflammatory and neuropathic pain models, the exact mechanism of action is as yet unknown Mechoulam and Hanus, ; Kress and Kuner, Unlike THC and related cannabinoids, phytocannabinoid-CBD, an important bioactive component of Cannabis sativa without psychotropic effect, is an antagonist of orphan G protein-coupled receptor 55 GPR55, a potential third metabotropic cannabinoid receptor without binding to CB1 and CB2 receptors Begg et al.
A particular focus has been on TRPA1 and TRPV1, two widely co-expressed ion channels found in CGRP expressing peptidergic nociceptors essential for neurogenic inflammation, oedema formation and inflammation-induced mechanical and thermal hypersensitivity Davis et al. Their activation by CBD in vitro results in desensitized responses following noxious stimulation with capsaicin or mustard oil, their respective agonists. This mechanism potentially decreases neuropeptide expression Bisogno et al.
In vivo absence or inhibition of TRPA1 results in reduced mechanical hypersensitivity in animal models of inflammation Petrus et al. Absence of TRPV1 in vivo reduces inflammation-induced swelling, thermal hypersensitivity and nociceptive behaviour in various pain models Caterina et al. In naive animals, TRPV1 immunoreactivity is localized in nociceptive primary afferents innervating the knee joint. After inflammation, TRPV1 expression increases not only in primary afferents, but is detected in synoviocytes which secrete lubricating fluid into the synovial space and function as local immune cells Kochukov et al.
Primary afferents are thus not only sensitized by peripheral release of pro-inflammatory cytokines, but are surrounded by cells that produce and release these molecules themselves.
Further studies are needed to identify specific receptors and mechanisms underlying the anti-inflammatory and anti-hyperalgesic effects of CBD. Transdermal CBD application was successful in decreasing monoarthritis-associated increases of pro-inflammatory biomarkers in neuronal tissues. In this study, the expression of CGRP in spinal cord was increased after peripheral inflammation as previously reported Sluka and Westlund, , and was decreased by high doses 6.
Like other neuropeptides, CGRP is rapidly transported to nerve terminals for release centrally as well as peripherally where as a potent vasodilator it contributes to neurogenic inflammation Kawasaki et al.
Although increases in CGRP are described in DRG after hindpaw inflammation Nahin and Byers, , no significant changes in DRG expression were observed here data not shown , possibly due to the small number of sensory neurons innervating the joint.
It is also plausible that by 7 days post monoarthritis induction, neuropeptide content has stabilized. In monoarthritic animals, spinal cord OX42 expression is increased in activated microglia, the immune cells specific to the central nervous system, as previously described for CFA-induced ankle inflammation and trinitrobenzene sulfonic acid TNBS -induced pancreatitis Shan et al.
Treatment with high doses of transdermal CBD in this study effectively reduced OX42 expression below baseline levels, indicating reduced microglial activation.
CBD is a known non-psychoactive cannabinoid, and due to its low affinity for the CB1 receptor it would be expected that exploratory behavioural activity would be similar among treatment groups compared to negative side-effects associated with THC Croxford, ; Malone et al.
This was demonstrated in this study by lack of CBD-induced changes in open-field exploration among naive treatment groups. Combinatorial with psychoactivity, side-effects such as hypothermia and hypomobility induced by THC are avoided with use of CBD Zimmer et al. These studies demonstrate transdermal administration of CBD has long-lasting therapeutic effects without psychoactive side-effects.
Thus, use of topical CBD has potential as effective treatment of arthritic symptomatology. The data presented suggest transdermal CBD is a good candidate for developing improved therapies for these debilitating disease. Stinchcomb, University of Kentucky start-up funds to K. Westlund and All-Tranz, Inc. Cannabidiol was a generous gift provided by NIDA. National Center for Biotechnology Information , U. Author manuscript; available in PMC Jul 1. Hammell , 1, a L. Zhang , 2, a F.
Abshire , 2 S. McIlwrath , 2 A. Stinchcomb , 1 and K. Author information Copyright and License information Disclaimer. The publisher's final edited version of this article is available at Eur J Pain. See other articles in PMC that cite the published article. Abstract Background Current arthritis treatments often have side-effects attributable to active compounds as well as route of administration. Results Measurement of plasma CBD concentration provided by transdermal absorption revealed linearity with 0.
Conclusions These data indicate that topical CBD application has therapeutic potential for relief of arthritis pain-related behaviours and inflammation without evident side-effects. Introduction Almost 50 million Materials and methods 2. Open in a separate window. Conclusion These studies demonstrate transdermal administration of CBD has long-lasting therapeutic effects without psychoactive side-effects. Cannabinoids and cannabinoid receptors have been studied as potential targets for reducing pain and inflammation associated with osteoarthritis and rheumatoid arthritis.
Cannabinoid side-effects vary and depend on several factors like administrated dose, route of administration, etc. What does this study add? Transdermal cannabidiol CBD gel application has therapeutic potential for relief of arthritic pain-related behaviours and exerts an anti-inflammation property without evident high brain centre psychoactive effects.
Footnotes Conflicts of interest None declared. All authors discussed the results and commented on the manuscript. Cannabinoids desensitize capsaicin and mustard oil responses in sensory neurons via TRPA1 activation. Role of ionotropic cannabinoid receptors in peripheral antipain and antihyperalgesia. Evidence for novel cannabinoid receptors. Synovial microparticles from arthritic patients modulate chemokine and cytokine release by synoviocytes.
Efficacy of two cannabis based medicinal extracts for relief of central neuropathic pain from brachial plexus avulsion: Results of a randomised controlled trial.
Molecular targets for cannabidiol and its synthetic analogues: Effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. Cannabinoids, endocannabinoids, and related analogs in inflammation. Impaired pain and pain sensation in mice lacking the capsaicin receptor.
CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain. Tetrahydrocannabinol inhibition of macrophage nitric oxide production. Oral anti-inflammatory activity of cannabidiol, a non-psychoactive constituent of cannabis, in acute carrageenan-induced inflammation in the rat paw. Naunyn Schmiedebergs Arch Pharmacol. A review of research into CBD and its possible mechanism of action suggested that CBD could play a role in chronic pain management.
CBD is available as an oil or powder, which it is possible to use to make creams or gels that people can apply to the skin of the areas affected by arthritis. It is a good idea to speak to a doctor before using CBD oil. A person should also educate themselves on the local laws regarding CBD oil, as the use of cannabis products is not legal everywhere.
Small-scale studies have found that people generally tolerate CBD well, but some individuals may experience mild side effects. It received approval for this use in June CBD is legal in some states in the U. Therefore, people should check the laws in their area before purchasing or taking CBD oil. Some people may have an allergic reaction to CBD oil, so it is best to try applying the oil to a small area of skin first.
CBD oil shows promise as a treatment for arthritis pain. If it affects receptors in the brain and immune system in the way that researchers believe, it may reduce inflammation and pain. However, more studies are necessary before researchers can say with certainty that CBD oil is an effective treatment for arthritis pain.
There is a selection of CBD oil available for purchase online. At a time when we are trying to reduce the use of pain relievers, CBD oil can be an effective approach to managing the pain of arthritis.
However, its effectiveness will vary from person to person. Work with your doctor to sort out the right balance of CBD oil, other medications, and self-care. This may work better than the medications you have been taking. We picked linked items based on the quality of products, and list the pros and cons of each to help you determine which will work best for you.
We partner with some of the companies that sell these products, which means Healthline UK and our partners may receive a portion of revenues if you make a purchase using a link s above. Article last updated by Yvette Brazier on Thu 2 August Visit our Osteoarthritis category page for the latest news on this subject, or sign up to our newsletter to receive the latest updates on Osteoarthritis.
All references are available in the References tab. Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medication Sativex in the treatment of pain caused by rheumatoid arthritis [Abstract]. Rheumatology , 45 1 , 50— FDA approves first drug comprised of an active ingredient derived from marijuana to treat rare, severe forms of epilepsy [Press release].
European Journal of Pain , 20 6 , — Involvement of the endocannabinoid system in osteoarthritis pain [Abstract]. European Journal of Neuroscience , 39 3 , — Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis [Abstract]. Pain , 10 , Cannabinoids in the management of difficult to treat pain. Therapeutics and Clinical Risk Management , 4 1 , — The abnormal cannabidiol analogue O reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55 [Abstract].
Neuroscience Letters , 1 , 72— MNT is the registered trade mark of Healthline Media. Here's some good news: Medical marijuana is helping people with arthritis improve their quality of life. Most of us know someone — an aunt, uncle or grandmother — suffering from arthritis.
The term "arthritis" is actually a category that includes over conditions and diseases affecting joints and surrounding tissue. Symptoms of pain, stiffness and swelling aching joints are common. Arthritis can seem inescapable and changes people's quality of life. There is no known cure.
There’s no known cure for arthritis, but marijuana works wonders
Cannabis can ease the pain and reduce the swelling of arthritis without the side effects No adverse health effects related to medical cannabis use have been reported, [36,37] Evidence from recent research suggests that cannabis-based . Recent studies demonstrated that administration of THC into mice triggered marked .. Rheumatoid arthritis is a chronic inflammatory disease that affects. Oct 30, Current arthritis treatments often have side-effects attributable to active compounds as This study examined efficacy of transdermal CBD for reduction in The THC-like cannabinoids act at CB1 or CB2 receptors, whereas.