CBD Oil Drug Interactions – The CYP Pathway. Research has begun to demonstrate that cannabidiol (CBD) has the potential to effectively help a large. OTHER NAME(S). 2-[(1R,6R)Methylpropenylcyclohexenyl] pentylbenzene-1 ,3-diol, CBD. . Show More · Read Reviews (47). CBD is a potent inhibitor of CYP3A4 and CYP2D6. ▫ As CYP3A4 metabolizes about a quarter of all drugs, CBD may increase serum concentrations of.
Interestingly, there is evidence to suggest cannabis may decrease insulin resistance, improve the metabolic process, and improve blood sugar control. However, most evidence comes from large epidemiological studies that analyze general patterns, including the causes and effects of various health conditions within specific populations.
Several studies found that cannabis users had lower rates of obesity and diabetes when compared to non-users. However, far fewer studies look specifically at how THC, CBD, or other cannabinoids interact with other drugs that have known effects on blood sugar like insulin.
But, by the same token, there could be a risk that cannabis combined with other drugs could lower glucose levels too much. Clearly, patients should continually monitor the effects under medical supervision to mitigate potential risks and adjust medication appropriately. Activating both receptors induces a cardiovascular stress response that can elevate cardiac oxygen consumption while reducing blood flow in coronary arteries.
While reports of adverse events are relatively rare, patients who are taking blood pressure medication should be aware that cannabis may compound effects. By possibly slowing down the metabolism of these drugs. To a lesser extent, THC may displace warfarin from protein binding sites.
However, characterizing the specific mechanisms by which they interact proves challenging. Nonetheless, the pain-relieving properties of cannabis are well-established.
And, many medical professionals have come forward to suggest cannabis as an alternative pain medication could play a role in stemming the overuse of prescription and illicit opioids.
However, what about as an adjunct to opioid therapy? How does cannabis measure up? Examining the subjective effects of vaporized cannabis in conjunction with opioids, Dr. Abrams concluded that cannabis can, in fact, safely augment the pain-relieving effects of opioids. His team also found that combining opioids and cannabis may allow for treating patients with lower opioid doses while reducing risk of dependency and fewer side effects.
Mixing alcohol with virtually any drug is generally not a good idea. In fact, mixing it with some drugs particularly opioids and central nervous system depressants like benzodiazepines, barbiturates, and sleep meds can prove fatal. But, what about alcohol and cannabis? But what does the research say? Is mixing these two substances okay? Overall, drawing a conclusion based on available research is subject to interpretation and personal biases.
The same studies can be interpreted positively or negatively, depending on your perspective. On the one hand, studies have provided compelling evidence that alcohol increases blood THC levels although no evidence suggests the converse—that THC increases blood alcohol levels. On the other hand, some research suggests people consume less alcohol when they use cannabis.
In fact, they make sense. If THC reacts to alcohol by potentiating the desired effects on mood, then one would need less alcohol. Concordance of Use by Men and Women , that examined consumption pattern differences in three different environments only alcohol is available, only cannabis is available, both are available.
Basically, when people have access to both substances, their consumption patterns change: That being said, one still needs to be cautious. For one, alcohol and cannabis together pose even greater dangers driving than when using either one independently. Second, if someone has had too much to drink—to the point they need to vomit to expel the toxins—know that cannabis inhibits nausea and vomiting. Many sedatives—such as alcohol, benzodiazepines Ativan, Valium, etc.
Although, each of these compounds produce effects differently, and sometimes paradoxically. For example, higher doses of THC can actually be stimulating and increase anxiety, while CBD can be both calming or wake-inducing.
When combined with sedatives, cannabis produces an additive effect. Users should exercise extreme caution, or better yet, avoid the combination altogether.
Although evidence suggests CBD is largely safe, well-tolerated, and non-addictive even anti-addictive , in some patients it can interact synergistically beneficially or adversely with other medications.
Most notably, the interplay between CBD and cytochrome P seems be most prominent when it comes to epilepsy and anti-seizure medications.
One small study published in found that CBD elevated blood concentrations of clobazam an anticonvulsant in children while elevating norclobazam an active metabolite of clobazam.
The good news is the remedy seems fairly straightforward: I know that sounds backwards and like I am confused but I am writing it correctly. We have the same problem with getting clinical trials done for Ketamine for depression. I am no doctor but if I had epilepsy I would try it. But I think you should do some reading of your own first and not just take my word for it. Remember when I said CBD at lower doses could make it worse? So please, please research this first without just taking my word for it.
You might even come across more detailed information and maybe even a suggested dose. I only wrote what I wrote because I know things are looking good for Epilepsy but like I said it seems like it might be a slippery slope finding the CBD sweetspot for Epilepsy. Good Luck and I hope after you research it yourself that it works great for you! Cbd saved my life. Your article here really helped educate me. I kicked opiates with pure cbd cantab tablets. Thank you so much for your comment.
I take and sell HempWorx and live in KY whuch is a heavily opiate addicted state. I want to educate people on how CBD can help, especially with the Feds closing the doors on several pain clinics lately. Congratulations on getting free of opiates. I used Suboxone which was harder to come off of than the opiates, especially cold turkey. Message me if you have any advice on how I can reach some of these patients without sounding like I just want to sell my product to them.
I also have tried coming off Suboxone which is indeed the most difficult of opiates to come off of. Any suggestions on disease and strength, etc. Do you know of information about interactions with blood thinners specifically, metoprolol or where I can find the information?
Thanks for your inquiry. The best person to speak to would be a doctor or pharmacist. Project CBD has a very good article on this subject. In addition, the sections on drug interactions in this presentation from Washington D. An interaction with CBD can cause elevated levels of another drug the person is consuming. Please be cautious and consult a medical professional. As I am not a doctor or medical professional, I cannot answer this question. My best advice is to consult your doctor or pharmacist.
These articles should have what they need to know about the mechanism of action of CBD in the body. Some people have managed to avoid CBD drug interactions by taking CBD at a different time than when they take their other drugs. Still I urge you to please get the OK from your doctor or pharmacist. Please consult with your doctor or pharmacist. CBD can alter the blood levels of another drug being taken.
I always recommend speaking to your doctor or pharmacist first before you start using CBD, just to be on the safe side. Most people do not have serious problems with drug interactions but again, always better to be safe. My vet of choice for these types of questions is Gary Richter. He is a well experienced veterinarian who has a lot of experience working with CBD.
Make sure to Google him and I bet he can answer you question. Unfortunately I do not know the answer as I am not a veterinarian. My veterinarian of choice who has a lot of experience working with cannabis is Dr. You may also be able to ask your vet this question and get an answer. I hope that helps. Have you heard of unwanted side effects for taking cbd oil with biologics and methotrexate?
The biologics and methotrexate have become less effective, either due to progression of my disorder or because my body has become resistant over the past 10 years. Thanks for your inquiry and I am sorry to hear about your condition. Unfortunately, I have never heard of unwanted side effects from this specifically. I recommend to speak with a doctor as soon as possible. I will be starting something new shortly. Can I take CBD oil whilst taking 25micro grams of throxrine, tramadol, paracetamol and ibuprofen?
Unfortunately I cannot answer that as I am not a doctor. Please check with your doctor or pharmacist. What I can tell you is that most people do not have problems with drug interactions and CBD. Still I urge you to be cautious and check with a medical professional. Unfortunately I cannot answer this as I am not a doctor. What I can tell you from my anecdotal experience is that most people do not have problems with drug interactions and CBD. Remember I am not a doctor so my opinion is not professional.
I would not think this would cause any problems but the best thing to do is just check with your doctor first. I hope you found relief from them. I take other heart meds, I wonder if they would interfer with the CDB. I would definitely get this checked with your doctor. Can you recommend any veterinarians in the Seattle area that are familiar with the use of CBD oil?
I recently adopted an older dog with hypothyroidism, arthritis, and muscle atrophy in his hind legs. I would like to find a holistic vet to treat his pain and arthritis. Any recommendations would be appreciated, thanks, Claudia. I know a very good vet in the SF Bay area named Dr. Richter is who I would recommend. If you are consistently noticing a negative side effect with him after using CBD, it may not be the right tool for him. I am sorry to hear about your wife.
I cannot help you with this inquiry since I cannot provide medical advice. Hi there Just started the CBD last week. I also have been and still am on a strong med called oxycodone. Have had croniv back pain for over 10 yrs. Really serious fibro for over 30 yrs. I also take lerica. I have cronic pain most of the day and night. One week with CBD , but no difference as of yet. Is it just time or increase CBD dosage? I am scared to ask my Dr. Thanks for your inquiry and clear explanation. Sorry to hear about the pain.
As long as you feel comfortable, you can increase the CBD dose to see if that would help. However 5mg is generally considered a small dose. I think this will change soon. If CBD is built up in your system over a few days, can the residual still have an effect on how p metabolizes drugs? I have been taking Ambien for sleep and tried CBD.
Took a large dose one day 30mg and 5mg 2x the following day. I ended up feeling drugged all day the following 2 days.
Rather than the 10 or we hours Ambien is supposed to stay in your system. CBD supposedly stays in your system days. Unfortunately this is beyond our area of expertise. Your best bet would be to speak to your doctor about this. Can I take CBB oil with my norco for post lisfranc foot surgery pain? I feel it will help wth the inflammation of the trauma.
Sorry to hear about your situation. I would speak again to your doctor about it and or get a second opinion from a different doctor.
You can speak with your pharmacist as well. I appreciate your ethics in that regard. I wish people would stop asking you to comment outside your scope of expertise. The question I do have is whether or not you can comment on how long it might take to notice the effects of CBD usage?
Is it, generally speaking, something I would notice right away say, an hour after dosing might it take a day or two to notice effects? Hey, thanks for your comment. I appreciate you understanding why I cannot provide medical advice. How are you taking it, in this case? Stupid if me not to give you all the information. My goal in CBD use is to reduce anxiety, which has become quite debilitating. If I have positive effects in other ways, so much the better. Great, thanks for the detailed information.
It sounds as if you are taking a typical serving size. I am pleased to hear you are working on this alongside a medical doctor. Most people experiment slowly until they find their sweet spot and what works best for them. With an oral dose the effects are typically felt within 1 hour. Let me know if you have more questions and I will do my best to help.
Hi, I was wondering why the THC is needed at all. Thanks for your excellent question. THC is not absolutely necessary. THC can have some side effects which people do not like.
Hi me again, I have two other questions wondering if you can clarify to any degree. I have read some of the research lit on CBD and other articles that extrapolate this info, but I do not have a clear idea on two particular facets: CBD is known to affect the human cytochrome P system, at what dosage or level does this occur?
Much of the research lists extremely high dosage levels.. Is there a known level where the effects on the P system begin to occur in humans? Can or does CBD use lead to a tolerance whereby increasing doses are needed for the same effects — or not? I appreciate you taking the time to do the research and ask these excellent questions. I lack the medical background to answer them. I am prescribed Solpodol and Paracetamol and when taking Palexia I seldom needed them!
Can you help me please? Thanks for your comment. But I can help you with general questions about CBD oil. Please consult with your doctor regarding medical questions and before using CBD oil. My husband has significant arthritis problems and benign tremors and would benefit from trying cbd but also must take warfarin due to having a 16 inch blood clot. Is it worth the risk? Please speak to your doctor or pharmacist about this. We do not have the medical background required to answer this question.
Please speak to your doctor. We do not have the medical background to answer that question. Please speak to your doctor and pharmacist about this. Study has been done on anti-seizure drugs for CBD liver enzyme interactions. I found out the hard way as I was using CBD to taper off Zoloft no interactions and it helped tremendously until I suffered exploding head syndrome and was diagnosed with severe anti-depressant discontinuation syndrome and had to go back on 50mg Zoloft to stop the major brain lightening strikes.
Also had to go back on clonazepam so I could sleep until zapping stopped. I never stopped taking CBD 30mg So I started on a roller coaster of one day being fine then having benzo withdrawal the next day. Once I figured it out and stopped CBD it took a few days to get better as CBD has a long half life so it can take days until you get a static blood level of clonazepam.
Time they take etc. Thank you for your question. Please speak to your doctor before using CBD. Best of luck to you. Out of all the questions people have asked you seem to have the same answer. So tell me what is the purpose of your site. But I will always help as much as I can, with product related questions mostly. No, you should not have to worry about any interaction with a medication you are taking since the topical CBD from the massage is not entering your bloodstream.
The only interaction to be possibly concerned with is with something else you are using on your skin, though I never heard of anyone having a problem with this. Please speak to a doctor or pharmacist who can help you get that answered. My pain killers do not work. I am also diabetic on Metformin. I am desperate to have less continuous pain. What can I do? I agree with your doctor. It would be best to speak with your pharmacist as they know all of your current medications.
You pharmacist and doctor may also want to monitor you while you take the CBD to make sure there are no negative interactions with the medications you are currently taking. Thank you for sharing such a important information, as rarely people know this use of CBD. We advise speaking to a doctor before starting. The problem is that CBD can alter the normal way your body processes the Warfarin, thereby changing its effects.
Please speak with your doctor before using CBD if you are taking Warfarin. Your doctor may want to monitor you closely if you decide to use CBD to make sure there are no issues with a drug interaction. I take two meds for prostate ,desmopressin tab and finasteride tab. I have arthritis and was thinking about cbd for pain. What kind of medicine do you mean when you say water pills? We recommend you speak with your doctor or pharmacist before mixing in CBD with your other medications.
Hi I had a disc fusion level 2 years ago and have been left with chronic pain in my neck which no medication seems to relieve I am on 3 different medications one being diazepam do you think I could try hemp oil while using these drugs Any information would be very useful to me Thanks Debbie. There is a possibility for a drug interaction between CBD and your other medications. I urge you to check with your doctor first as they may want to monitor your blood levels of other medications you are on.
Project CBD just released an excellent paper on drug interactions which you should download and check out. Hi thanks for your question. Project CBD has also released a new report on drug interaction for which we highly recommend you check out. Visit Project CBD to download the report. Can I buy book I am not professional I have some concern medicaltion issue with cbd oil interact issue thank you. Click here to check out our article about the best books on CBD.
Please let us know if you have other questions. We recommend you check that out over at the Project CBD website. CBD may interact with pain medications. Some people find this interaction beneficial because it allows them to take less of their opiate medications and avoid side effects and addiction to the opiate pain killers.
Still I recommend you speak with a doctor and your pharmacist first, before using CBD. I also recommend you review the brand new report just published over at Project CBD on drug interactions. You can go to the Project CBD website and download it for free. Let me know if you have more questions please. Unfortunately we at CBD School do not have the medical background to answer specific questions.
My recommendation is to speak to a doctor or pharmacist for this specific inquiry. Can I safely take CBD oil with these prescription drugs: I have been sober for over 25 years.
Which is the primary trigger of my PTSD. Will it get me high? Thanks for your comment and question. CBD is non-addictive and non-intoxicating. Many people report that CBD does help with their pain. A more concentrated CBD product example would be a tincture or a capsule. I recommend you speak with a medical professional who knows your current medications before you start using CBD.
I am currently taking 2. My recommendation is to speak to a doctor or pharmacist for this specific inquiry about this medication and CBD. My recommendation is to speak to your doctor or a pharmacist for this specific inquiry about this medication and CBD. Thanks for your feedback. We always recommend checking with your doctor before starting to use CBD, especially if you are taking other medications already.
Hi can u take cbd. Many people do find that CBD helps them be less anxious. There are indeed some theories that CBD may have to build up in your system to get the most benefits. However I have never seen any evidence for this. Any known drug interactions with these and CBD oil? Unfortunately we at CBD School do not have the medical background to answer specific questions like the one you asked.
I have a friend who has the autoimmune condition Lupus, and wanted to try CBD oil to treat it. I got him a bottle, but he was reluctant to take it because: He wanted to discuss the issue with his doctor, but keeps forgetting to mention the issue during his last visit. The oil that I got for him was mixed with coconut oil, which he is allergic to because of his Lupus condition. He told me that he takes Warfarin, and is concerned about possible interactions with it.
What should I advise him. Would CBD oil be appropriate for him? Thanks for your great questions. I answered your questions below. Please write me back if you have more! Yes, he absolutely needs to discuss this with his doctor first. There are plenty of CBD products out there without coconut oil. Bluebird Botanicals CBD tincture is just one example.
They use hemp seed oil instead of coconut oil. He absolutely needs to check with his doctor first. The doctor may request to monitor his blood levels while he takes the CBD to make sure there is no negative interaction with Warfarin. Please be careful about this. Always talk to the doctor before starting CBD.
How Does Cannabis Interact With Other Drugs?
Cannabidiol: learn about effectiveness, usual dosage, and drug interactions on MedlinePlus. CBD is a very promising new treatment method for many different conditions. Like any other treatment, though, there can be interactions with other meds. CBD-Drugs Interactions. Today we are about to address a quite sensitive issue – the interaction of pharmaceutical drugs and cannabidiol. Although the CBD.