Cannabidiol (CBD) is a primary component of cannabis. CBD and THC are the most prominent cannabinoids found in cannabis, and as such have undergone the heaviest scientific study. CBD products come either from medical cannabis or industrial hemp plants. Here are 10 facts you need to know about CBD. Cannabidiol, otherwise known as CBD, and THC are usually the most common cannabinoids in the plant and. 5 things you didn't know about CBD, straight from industry experts (In fact, clinical trials have shown you'd need to ingest a dose equivalent to.
You Need More Learn | 10 to Facts CBD Know
The high is caused by THC. CBD does not bind to these receptors and instead causes its therapeutic actions through more indirect means.
Because CBD will not make you feel intoxicated, it is a great option for parents, workers, and anyone else who does not to compromise their mental clarity. Many health conditions, both severe and not, are treated with pharmaceutical drugs. Unfortunately, many of these drugs have unpleasant or dangerous side effects.
In some instances, CBD may offer non-toxic, virtually side-effect free, natural benefits for individuals who want to avoid or reduce the number of pharmaceuticals they are taking. CBD products come either from medical cannabis or industrial hemp plants. While still illegal under federal law, cannabis is legal in several states. This means that consumers are free to choose CBD as a natural supplement without worrying about any legal repercussions.
Phytocannabinoids are cannabinoids derived from plants. Endocannabinoids are cannabinoids produced naturally in the human body.
An enzyme in the body known as FAAH is responsible for breaking down anandamide. Anandamide has been shown to stop the proliferation of breast cancer cells , promote anti-anxiety and antidepressant effects, and increases neurogenesis.
Anandamide plays a role in memory and forgetting , creating a potential natural value for individuals with post traumatic stress disorder PTSD. CBD is an allosteric modulator at several receptor sites in our bodies. Allosteric modulators change the shape of specific receptors to alter their ability to interact with neurotransmitters. CBD is a positive allosteric modulator of the mu and delta opioid receptors.
This means it enhances the ability of these receptors to receive endogenous enkephalins which can increase quality of life and naturally reduce pain. At high doses , CBD activates the 5-ht1A receptor. The 5-ht1A receptor helps regulate anxiety, addiction, appetite, sleep, pain perception, nausea, and vomiting.
GPR55 receptors are widely distributed in the brain especially the cerebellum and help to control bone density and blood pressure. When activated, GPR55 promotes cancer cell proliferation.
This antagonizing action may help explain the natural value of supplementing with CBD in individuals with cancer, osteoporosis, and high blood pressure. TRPV1 is involved in regulating pain, body temperature, and inflammation. Clinical Endocannabinoid Deficiency is a condition where an individual has a lower amount of endogenous cannabinoids than is considered necessary to promote health and well-being.
Scientists now believe CECD may play a role in the following conditions: Many of these conditions are treated with a range of medications that carry some heavy side effects. As the research develops, if CECD is found to be the culprit behind these conditions, CBD would help increase endocannabinoids in the body without many of the risks associated with pharmaceuticals.
In other words, it is the sum of its parts that make cannabis so effective. For example, mg of isolated CBD may be substantially less effective at alleviating symptoms than mg of a whole-plant, cannabis extract.
Vitamin C may be a good analogy. Many vitamin C supplements are presented in the form of ascorbic acid. Ascorbic acid is just one of the many compounds that comprise the whole vitamin C. In fact, in all of his years of research, the discoverer of Vitamin C and Nobel prize laureate Dr.
CBD oil mixed with a carrier oil can also be taken as soft-gel capsules to avoid any taste, but absorption is only through the intestinal tract. The average dose range is mg of CBD, one to three times per day, though much higher doses of mg sometimes required to control pain are equally well tolerated. Some people will notice benefit at the lower end of the dose range, but most people will need mg to notice any effects.
Because different products provide different concentrations of CBD, the packaging usually states how much CBD is in the entire bottle as opposed to the amount in a certain number of drops or dropperfuls, so measuring can be a little tricky. A dropperful of the medium grade product mg of CBD per fluid ounce will deliver about 15 mg of CBD — a good starting dose. And a dropperful of a high concentration product mg CBD per fluid ounce will provide about 50 mg of CBD per dropperful.
CBD oil is also available as soft gel capsules. With these, the mg quantity of CBD should be designated per capsule. Because some of the chemical compounds in capsules are lost during digestion, you may find you need to take a little more to experience the benefits. As with any medicinal herb, start at a low dose and gradually build up to a higher dose as you get used to the effects of the substance. Most people notice benefits almost immediately, but some experts suggest that full benefit does not occur until after a couple of weeks of consecutive use.
CBD isolate which is CBD alone acts very differently in the body than a spectrum of hemp chemical components. Here are some quick definitions:. The cannabis plant naturally generates cannabinoids, terpenes, and other chemical compounds to serve different functions in the plant.
These functions include regulatory properties, potent antioxidants, and protection from microbes and insects. Any creature that consumes the chemicals from the plant gains these same benefits. When you consume CBD oil, you gain the benefits of all those chemical substances in natural synergy. For that reason, you get full benefit at a dose range of mg. CBD isolate is limited to that single chemical messenger.
The synergy provided by the full spectrum of chemicals in CBD oil is lost. This is likely why clinical studies using purified CBD require very high doses, in the range of mg of CBD several times daily, to see a benefit. When CBD is formally legalized at the national level, prescription drugs providing high doses of purified CBD will become available several are already in the pipeline. Reported side effects of hemp oil with CBD are generally mild and uncommon and can include tiredness, loose stools, and mild changes in appetite and weight either increased or decreased.
Both hemp oil with CBD hemp flower-bud extracts and purified CBD CBD isolate have been shown in both animal and human clinical trials to be remarkably safe and well tolerated. Prolonged use is not associated with an increased risk of side effects. In research studies , up to mg of purified CBD per day has been used to address various medical illnesses without reported harmful effects including changes in heart rate, blood pressure, temperature, oxygen and carbon dioxide levels, electrolyte balance, gastrointestinal function, psychomotor functions, or sleep cycles.
Prolonged use at high doses has not shown potential for abuse of CBD. In fact, a clinical study published in found that recreational polydrug users did not show abuse potential with use of CBD. Long-term studies have not evaluated potential changes in hormonal balance or long-term adverse changes in liver function, though prolonged use of CBD enhances metabolism of certain drugs. Stopping CBD oil suddenly has not been associated with withdrawal effects.
While the cost of CBD oil products is presently high, it will likely come down dramatically after CBD and hemp are legal by federal standards — but prices will still vary widely.
Reputable companies selling CBD oil products will state the CBD concentration and extraction methods on the bottle or website. Typically, the concentration is stated as milligrams mg of CBD per fluid ounce though some products standardize mg of CBD to milliliters ml. The benefit comes from the amount of CBD consumed, not the amount of oil. To calculate the cost per milligram of CBD, simply divide the dollar amount of the product by the total milligrams of CBD in the bottle.
As for extraction methods, remember that vapor distillation and CO2 extraction are preferred. Lipid-based extractions will likely fall in the middle price-wise.
The highest quality cannabis is grown indoors , so quality standards can be controlled. Use of clean water and organic methods of farming that are free of pesticide use and unnatural fertilizers are, of course, preferred. With outdoor-farmed cannabis, quality standards and potency are not as easily controlled.
Taste can be a sign of value, too. Poor quality oils will have a very unpleasant chemical taste, and they can cause significant burning to mouth tissues.
A good quality product should be smooth and not cause significant burning. Interestingly, the best quality products are associated with a distinct cannabis taste, indicating that the full spectrum of chemical components with trace levels of THC are present. Even in high doses, CBD oil will not cause euphoria or impair coordination, balance, or motor functions.
Use of CBD oil is associated with improved sense of well-being, but not an exaggerated feeling of well-being. Use of CBD oil has never been associated with hallucinations or abnormal mental activity.
Creams and salves for musculoskeletal discomfort generally contain very small amounts of CBD that are absorbed through the skin. Many of these products do provide significant benefit, however, but the benefit is likely derived from other aspects of CBD — especially terpenes from cannabis and essential oils, thanks to their anti-inflammatory properties.
Though CBD will likely become a highly promoted ingredient in beauty products, it is unclear whether the concentration of CBD present in these products will provide a benefit. There is near zero potential of becoming habituated to hemp CBD products. It should be noted that recreational use of marijuana high THC, low CBD cannabis does result in dependence but different from narcotics or alcohol, and not as debilitating. Chronic use of THC may be associated with atrophy in certain areas of the brain and reduction of certain cognitive functions at this point, studies are not conclusive.
Interestingly, studies have shown that taking CBD oil regularly can restore areas of the brain that have become atrophied in marijuana abusers. There have been no reports of anyone overdosing on cannabis. This sets even recreational use of cannabis widely apart from narcotics and alcohol, both of which can cause severe respiratory depression and death at excessive doses.
Excessive doses of hemp, and more especially, marijuana, may make you very agitated and feel terrible, but there are no known deaths from cannabis overdose. Many food and beverage companies are already taking advantage of the growing CBD trend and adding CBD to food and beverage products, though the practice is not approved by the FDA. Using CBD in defined doses for medicinal purposes is one thing, but putting it in food and beverages is something entirely different.
Someone may wind up getting CBD from multiple products, and so their daily dose could vary significantly. Taking a standardized dose of CBD oil daily as a recognized medicinal is a very different thing from taking uncontrolled doses of CBD isolate daily infused artificially into food and beverage products, and the long term risk may be very different — no one really knows for sure.
Like most herbs, cannabis does have some antimicrobial and immune-boosting properties, but it is not as strong an antimicrobial as many other herbs.
There are many better herbal choices for overcoming chronic Lyme disease and similar conditions related to chronic infections with stealth microbes such as fibromyalgia and chronic fatigue syndrome.
The bottom line is, CBD oil is a good option for controlling symptoms associated with Lyme disease, fibromyalgia, and other chronic illnesses, but it should be combined with other antimicrobial and immunomodulating herbs for optimal benefit.
CBD oil is best used intermittently to treat symptoms of pain or anxiety, or used chronically only until symptoms gradually resolve, and then discontinued. The story around CBD will continue to change and evolve once hemp is legalized and as the industry continues to grow and advance.
Rawls is a physician who overcame Lyme disease through natural herbal therapy. You can learn more about Lyme disease in Dr. You can also learn about Dr. Bill Rawls practiced conventional medicine for 15 years. However, when Lyme disease and fibromyalgia disrupted his career at age 45, he was forced into the world of herbal and alternative medicine.
He has since restored his health—and has a passion to help others do the same. Everything You Need to Know. Why did humans start using cannabis? How are hemp and marijuana different? What are terpenes, and why are they important?
What are the benefits of taking CBD? What are the potential side effects of CBD oil? How much does hemp oil with CBD cost? Will I get high from using CBD? Will using CBD make me fail a drug test? How effective are topical CBD products? Can you get hooked on hemp CBD products? Can you overdose on cannabis? Are foods and beverages with purified CBD safe?
Cannabidiol CBD and its analogs: Blessing EM et al. Cannabidiol as a Potential Treatment for Anxiety Disorders. Devinsky O et al. Cannabidiol as an Intervention for Addictive Behaviors: A Systematic Review of the Evidence. Massi P et al. Cannabidiol as potential anticancer drug. Br J Clin Pharmacol.
Bergamaschi MM et al. Safety and side effects of cannabidiol, a Cannabis sativa constituent. Hurd YL et al. Crippa JA et al. Toward a New Age. Bruni N et al. Schoedel KA et al. Abuse potential assessment of cannabidiol CBD in recreational polydrug users: A randomized, double-blind, controlled trial.
5 Mind-Blowing Facts You Need to Know About CBD
10 Things You Need to Know Before You Buy CBD Oil Although more people are becoming aware of the health benefits of CBD oil, many still associate it with . Scientists studying the health benefits of CBD have found it is a promising is replaced by new at a rate of about 10 percent per year, crucial to maintaining strong, In fact, historical documents show that cannabis preparations have been. You've probably heard so much buzz about CBD oil in the mainstream media that you're feeling a buzz yourself. All that talk may have you.