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These days, however, people are most excited about the properties of a chemical component of hemp called CBD, short for cannabidiol — myself included. This chemical component has been linked with reduction of pain and seizures, improved mood and sleep , protection of the nervous system, and a range of other health benefits. Subscribe to our Facebook and YouTube to get updates when new episodes are posted. Unlike marijuana, hemp is legal in all 50 states according to state laws.
On December 20, , the president signed the Farm Bill, which replaced the version that expired in September. It includes the Hemp Farming Act of , which makes the use and sale of products made from hemp completely legal across the nation. It does not affect the legal status of marijuana. However, the CBD market has all the makings of a wild west show, with many businesses anxious to get in on the action and make a tidy profit.
And with no official system of checks and balances, it will be hard to tell how much CBD is actually present or what quality it is. Learning how to make informed choices which choosing and using CBD will help you gain the most benefit from this unique and powerful plant extract.
Can hemp oil with CBD treat Lyme disease, fibromyalgia, and other chronic illness? Cannabis sativa was one of the earliest plants cultivated by humankind. The very first use of cannabis was documented in China around BC. A very versatile plant, it was used for food, medicine, religious and spiritual rituals, industrial fiber, and, of course, recreation. From China, cannabis spread to India, the Arabian Peninsula, and then on to Europe with the spice trade. Through European colonization, use of cannabis spread to the Americas, Caribbean, and throughout the world.
How the plant was used depended on the variety of cannabis, the parts of the plant, and how the plant was cultivated. The variety of cannabis known as hemp was traditionally valued primarily for its fibers with high tensile strength, making it ideal for creating rope and textiles. Hemp seeds and sprouts were eaten as a good source of high-quality protein and beneficial omega-3 fatty acids. The variety of cannabis known as marijuana was specifically cultivated for the euphoric properties of THC, which is concentrated mostly in the flower buds of the plant.
Only recently have the unique medicinal properties of both hemp and marijuana been fully recognized. Cannabis sativa has several alter egos, but marijuana and hemp are the two best known.
Though both plants look the same, their chemical composition is quite different. The chemical difference has to do with the presence or absence of certain enzymes. Both marijuana and hemp contain a chemical substance called cannabigerol CBGA , which is concentrated mostly in the flower buds of the plant.
Remember, though, that there are many varieties of marijuana and hemp plants, and their concentrations of THC and CBD vary. Only cannabis with less than 0. There are different receptors for cannabinoid compounds located throughout the body. For instance, CB1 receptors are found in high concentrations in the brain and nervous system. CB2 receptors are located throughout the body, but predominantly within the lower body and immune system.
It weakly binds to both CB1 and CB2 receptors in the brain and body, gently stimulating and blocking them at the same time. This not only mildly activates the receptors, but is also thought to trigger the body to create more CB 1 and CB 2 receptors, a process known as upregulation. It also results in increased natural levels of anandamide. When the body experiences an increase in CB receptors, it becomes more sensitive to the natural endocannabinoids anandamide and others already present in the body.
CBD also modulates other receptors in the body. For instance, modulation of the 5-HT1A receptor involved with serotonin, a mood hormone provides mood-balancing properties: Another example is modulation of opioid receptors, which provides pain relief and tissue-supporting properties. Cannabis plants also possess a wide spectrum of different chemical components offering a range of medicinal properties. Aside from cannabinoids, one of the most prominent chemicals in cannabis plants is terpenes, organic and aromatic compounds found in essential oils.
Terpenes are beneficial on their own. For instance, research in the British Journal of Pharmacology found that terpenes are gastro-protective, suggesting they may be beneficial to people with ulcers, and that they have anti-inflammatory properties. It also points to the importance of using a full-spectrum extract of hemp, which provides a full range of chemical components including terpenes, as opposed to purified CBD or CBD isolate, which contains only CBD.
Cannabinoids, including cannabidiol CBD , work by mimicking natural endocannabinoids like anandamide described above in the body. Endocannabinoids are part of a complex messaging system in the body called the endocannabinoid system. The endocannabinoid system oversees or regulates parts of the nervous system, endorphins, immune system functions, hormones, mood and emotions, metabolism, and many other chemical messengers in the body.
Like other cannabinoids, CBD readily crosses the blood brain barrier, making it ideal for affecting central nervous system conditions. CBD helps calm the nervous system, reduces inflammation, and is strongly neuroprotective. Not surprisingly, clinical studies evaluating cannabidiol for treatment of anxiety , post traumatic stress disorder PTSD , seizure disorders especially childhood seizures , and even schizophrenia have shown remarkable effectiveness.
Management of chronic pain is another application for which CBD is ideally suited, and it works in a number of ways. It and other non-THC cannabinoids found in hemp flower-bud extracts work to block pain-conducting nerve impulses, which reduces your perception of pain.
Stimulation of CB 1 in the brain increases dopamine , which counteracts pain. Just as importantly, these same chemical substances reduce inflammation , the driving force behind pain , which allows healing to occur. CBD and other cannabinoids also reduce pain by affecting endorphins, the feel-good chemicals we naturally produce to suppress pain.
Unlike opioids heroin, narcotics , which mimic endorphins and ultimately suppress natural endorphins, cannabinoids modulate endorphins. This means, in effect, that CBD and cannabinoids increase natural endorphins. So instead of causing dependence and addiction like opioids, CBD and cannabinoids do the opposite — so much so that CBD has proven valuable for countering narcotic and cocaine addiction.
From a medicinal standpoint, the fact that CBD has the potential to relieve pain without causing euphoria, intoxication, or addiction makes it an intriguing therapeutic option — it has high potential for being at least a partial solution to the current opioid epidemic.
CBD and other chemical substances in hemp flower-bud extracts are strong immune system modulators. This means they control inflammation throughout the body, and also fine-tune the immune system for optimal performance. The wide range of benefits associated with cannabis have garnered interest for use in cancer therapy.
Research suggests that cannabinoids, including CBD, may have anti-tumor effects. While this is not enough to define cannabis as a treatment for cancer, it does make it attractive as a complement to other therapies , for both reducing symptoms and possibly enhancing the effects of anticancer drugs. Terpenes and the wide spectrum of other chemical compounds found in hemp flower-bud extracts provide potent anti-inflammatory and antioxidant properties.
This is a common source of confusion. Many people see hemp oil on grocery store shelves and assume or wonder if it contains CBD and other cannabinoids. The hemp oil you might see on grocery store shelves is made by cold pressing hemp seeds. While hemp oil is a healthful option for a salad dressing, it has no medicinal value by itself. Cannabinoids, including CBD in hemp and THC in marijuana, are most highly concentrated in the flower buds, not the seeds.
These chemical components of the plant must be extracted from the flower buds to be useful. For medicinal use, cannabinoids are extracted from hemp and concentrated into a thick oil that, when ingested, elevates blood levels of cannabinoids for a more sustained period of time. CBD oil from hemp contains CBD and other cannabinoids, along with terpenes and other chemical components. The most common method, chemical extraction uses alcohol or hexane as solvents. The solvent is dried off, leaving the dense oil — and possibly harmful residual solvents — behind.
A newer method, CO 2 extraction is done without using chemical solvents. Instead, it uses carbon dioxide to extract the full range of chemical components from the flower buds and then distill them into dense CBD oil. Also sometimes called thermal extraction, vapor distillation uses hot air to safely vaporize the full spectrum of chemical components at high concentration from the buds, and then the vapor is distilled into CBD oil.
This method also activates the cannabinoids by removing an extra carboxyl ring from their molecular chain a chemical reaction called decarboxylation , enabling them to interact directly with CB receptors for maximal medicinal value. I believe vapor distillation is the best method for obtaining the full range of activated chemical compounds from the cannabis plant. This method preserves the terpenes, which are beneficial on their own, and also enhance the properties of CBD via the entourage effect.
The upsides of lipid-based extraction are that the fat helps make the CBD more bioavailable easy to absorb , and there are no harsh solvents used. Condensed CBD oil can be taken as a thick paste, but this is the least pleasant option. More commonly, the CBD oil is mixed with a carrier oil, such as hemp oil or coconut oil, to a specific concentration of CBD.
The distinctive taste — which comes from the terpenes and not the cannabinoids — is often masked with chocolate, mint, or other flavorings. It typically comes in a small bottle with a dropper to administer the oil mixture. The best way to take CBD oil mixed with a carrier oil to a specific concentration is to place a few drops or dropperfuls under your tongue for 15 seconds to access the sublingual gland.
There, the CBD is absorbed directly into the bloodstream called sublingual consumption or administration for the fastest acting effects. Another method is to take a few drops or dropperfuls orally, swish the liquid around in your mouth, and then swallow it.
CBD oil mixed with a carrier oil can also be taken as soft-gel capsules to avoid any taste, but absorption is only through the intestinal tract. The average dose range is mg of CBD, one to three times per day, though much higher doses of mg sometimes required to control pain are equally well tolerated.
Some people will notice benefit at the lower end of the dose range, but most people will need mg to notice any effects. Because different products provide different concentrations of CBD, the packaging usually states how much CBD is in the entire bottle as opposed to the amount in a certain number of drops or dropperfuls, so measuring can be a little tricky.
A dropperful of the medium grade product mg of CBD per fluid ounce will deliver about 15 mg of CBD — a good starting dose. And a dropperful of a high concentration product mg CBD per fluid ounce will provide about 50 mg of CBD per dropperful. CBD oil is also available as soft gel capsules. With these, the mg quantity of CBD should be designated per capsule. Because some of the chemical compounds in capsules are lost during digestion, you may find you need to take a little more to experience the benefits.
As with any medicinal herb, start at a low dose and gradually build up to a higher dose as you get used to the effects of the substance. Most people notice benefits almost immediately, but some experts suggest that full benefit does not occur until after a couple of weeks of consecutive use. CBD isolate which is CBD alone acts very differently in the body than a spectrum of hemp chemical components. Here are some quick definitions:. The cannabis plant naturally generates cannabinoids, terpenes, and other chemical compounds to serve different functions in the plant.
These functions include regulatory properties, potent antioxidants, and protection from microbes and insects. Any creature that consumes the chemicals from the plant gains these same benefits. Over the course of this double-blind, placebo-controlled study, 38 participants were given either a placebo or variable dose of CBD. This is obviously a rollercoaster of a study which found that the ups and downs of the ride did not change based on whether the participant received a placebo or CBD.
Again, this can be good news or bad depending on the point of view: CBD might not affect how one emotionally views the world, which is great because that is one side-effect less to a potential health therapy. It should be noted that this study seems to be at odds with other studies in this list that say CBD is a potential therapy for anxiety. Regardless, de Wit makes the apt point: Schizophrenia is a disorder that generally requires heavy antipsychotic drugs just to manage daily life.
As discussed in the review, CBD may be a possible alternative to such heavy prescription drugs. CBD has both anti-inflammatory and anti-psychotic characteristics.
Thus, the aim of the review was to evaluate literature both preclinical and clinical on the effects of CBD in relation to schizophrenia. The authors looked through 27 articles from the past 26 years. Due to the lack of clinical evidence, the level and effectiveness that CBD might have cannot be clearly stated. The review is nonetheless an excellent starting point for the future use of CBD in neurological treatments. The goal of this study is to find an alternative to heavy pain medication, which can lead to prescription drug-abuse.
Of those who had reported using an opioid medication for pain in the six months prior to the survey, the following responses were gathered after cannabis-use:. While the survey is not specifically about CBD, this is an important area of research into the non-addictive nature of cannabis and lack of side effects that accompanies its use. Also, not only is it effective on its own but it can also aid the current use of opioids and decrease the need for such medication.
Ultimately, CBD may one day be a viable replacement for pain-management medications. Full disclosure, this is not a published study yet, but the announcement itself is worth including in this list. The study will include adults with HIV as this group, compared with the general public, has higher levels of chronic pain and opioid use. This is particularly exciting news as it is the first long-term study of this question.
DO; Gerich, Mark E. MD; Hoffenberg, Edward J. MD; Collins, Colm B. As noted in this review , while modern medicine does tend to allow people to live relatively normal lives, the medicines used to treat IBD can have limited benefits and lose effectiveness.
The ECS is a biological system within mammals that is made up of three components: The review notes that incidents of IBD are on the rise, which reinforces the need for research into new potential therapies. This study investigated how CBD could affect subjects with liver injuries resulting from chronic and binge alcohol consumption.
CBD was given to subjects in this case, mice and human blood samples that had been fed alcohol. In short, the analysis demonstrated that CBD lessened the elevated liver enzymes and the increased liver triglyceride. It also reduced fat droplet accumulation. Also of note, CBD improved the alcohol-induced liver metabolic impairment and abnormal retention of lipids. Arterial Ischemic Stroke occurs when blood flow in an artery to the brain is blocked due to narrowness of the artery or the formation of a blood clot.
Currently, there is no effective treatment. This study demonstrated CBD can reduce brain damage and improve recovery , at least in the neonatal Wistar rat subjects studied. CBD reduced all of the following: Crippa, and Wiliam A. This study analyzed whether the application of CBD has an effect on pain in the varied ways it can be perceived and experienced.
The research yielded several results. The findings from these studies are broad, ranging from treatment of serious disorders to quirky ancillary information. Fundamentally, the true importance of these studies and reviews is the fact that many of them, and the researchers behind them, are building from earlier findings, theories, and research efforts. Their impact is not only the actual results but the way those results echo into the CBD research field.
These studies are a call to action, reflecting the vast need to dig deeper into the potential benefits of CBD as an alternative treatment for so many disorders. More research, trials, and studies are needed to fully understand the long-term effects and benefits of this potentially game-changing way to approach treatments. My brother recommended I might like this website.
He was totally right. This post truly made my day. Your email address will not be published. January 17, Blog 1 Comment. Over the course of this year and many years prior Cannabidiol has been shown to be a potential therapy for: CBD studies with the greatest impact over the past year Over the past year, hundreds of CBD-related studies were conducted across dozens of countries and institutions.
CBD has comparatively fewer side-effects compared with prescription medication The fewer side-effects could help increase patient-adherence to treatment CBD can be used as a supplemental therapy To put the CBD side-effects in perspective, other drugs used for the same medical condition have far more negative side-effect profiles.
Study Parameters and Results A group of 15 patients who received CBD over a period ranging from one month to one year were surveyed to gather various data. This simple observational study identified some very encouraging findings: Level of patient-control over seizures: Many patients experienced improvements in behavior, language, sleep, and eating habits. Most common were drowsiness and fatigue.
Trial Parameters and Process The parameters of this trial are particularly impressive and add to the integrity of the results: Double-blind Placebo-controlled Subject pool of children and young adults with Dravet syndrome and drug-resistant seizures Over the course of a week treatment period, the subjects were randomly assigned either a daily dose of CBD oral solution based on body weight or a placebo.
The findings of this study could have a huge impact on PTSD management. The subjects were divided into 5 groups who randomly received either a placebo, CBD in mg, mg or mg, or clonazepam a medication used to treat panic disorders following the experimental procedure in the graphic below: Results Clonazepam was the obvious front runner, consistently reducing anxiety in a more sedative way than the placebos and CBD administration. Soares and Alline C. Tan, and Saoirse E. The Misinterpretations The study authors noted that both prior studies were severely misinterpreted.
While CBD might convert to THC under certain simulated acidic conditions, it has not been shown to actually occur in living organisms. This is a classic misinterpretation of what could happen in practicality based solely on culture-dish tests results.
The results of the human volunteer tests were taken out of context. Traces of THC were not only extremely minimal in the human volunteers but the alleged THC was not present in urine samples. Study Parameters Over the course of this double-blind, placebo-controlled study, 38 participants were given either a placebo or variable dose of CBD.
Perceptual sensitivity to emotional facial expressions Attentional bias toward emotional facial expressions Feelings of social rejection This is obviously a rollercoaster of a study which found that the ups and downs of the ride did not change based on whether the participant received a placebo or CBD.
The Impact Again, this can be good news or bad depending on the point of view: CBD might not be an effective treatment for anxiety itself. Fibromyalgia Neurological disorders e. Epilepsy Due to the lack of clinical evidence, the level and effectiveness that CBD might have cannot be clearly stated. Of those who had reported using an opioid medication for pain in the six months prior to the survey, the following responses were gathered after cannabis-use: CBD and Opioid Use:
The Science Behind CBD Oil: Everything You Need to Know
The health benefits of CBD oil are being studied by world-class researchers around the world. We analyzed and summarized 17 of the best CBD studies of Published in June, this review evaluated a massive amount of existing research, data, and .. twitter · facebook · youtube · google+ · instagram. CBD oil. (Credit: ELRoi/Shutterstock). One of the most controversial drugs in a Dutch cannabis researcher, observed in a recent review. CBD and Hemp Oils Reviewed by es3.info and abnormal results on liver-function tests (Devinsky, New Eng J Med ).